Publications

High Impact Publications

 

• Atrial Fibrillation in Patients with Cryptogenic Stroke
  Gladstone DJ, Spring M, Dorian P, Panzov V, Thorpe KE, Hall J, Vaid H, O’Donnell M, Laupacis A, Côté R, Sharma M, Blakely JA, Shuaib A, Hachinski V, Coutts SB, Sahlas DJ, Teal P, Yip S, Spence JD, Buck B, Verreault S, Casaubon LK, Penn A, Selchen D, Jin A, Howse D, Mehdiratta M, Boyle K, Aviv R, Kapral MK, Mamdani M, for the EMBRACE Investigators and Coordinators.  Print Publication – New England Journal of Medicine
• Presentation Blood Glucose and Death, Hospitalization, and Future Diabetes Risk in Patients with Acute Heart Failure Syndromes
  Sud M, Wang X, Austin PC, Lipscombe LL, Newton GE, Tu JV, Vasan RS, Lee DS.  Print Publication – European Heart Journal
• Cardiometabolic Consequences of Gestational Dysglycemia
  Brewster S, Zinman B, Retnakaran R, Floras JS. Print Publication – Journal of the American College of Cardiology (JACC)

• Cost-Effectiveness of Apixaban vs. Current Standard of Care for Stroke Prevention in Patients with Atrial Fibrillation
  Dorian P, Kongnakorn T, Phatak H, Rublee DA, Kuznik A, Lanitis T, Liu LZ, Iloeje U, Hernandez L, Lip GYH. Print Publication –  European Heart Journal

• Dantrolene Improves Survival After Ventricular Fibrillation by Mitigating Impaired Calcium Handling in Animal Models
  Zamiri N, Massé S, Ramadeen A, Kusha M, Hu X, Azam MA, Liu J, Lai PFH, Vigmond EJ, Boyle PM, Behradfar E, Al-Hesayen A, Waxman MB, Backx P, Dorian P, Nanthakumar K. Print Publication –  Circulation

• Factors Associated With Major Bleeding Events: Insights From the ROCKET AF Trial (Rivaroxaban Once-daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation)
  Goodman SG, Wojdyla DM, Piccini JP, White HD, Paolini JF, Nessel CC, Berkowitz SD, Mahaffey KW, Patel MR, Sherwood MW, Becker RC, Halperin JL, Hacke W, Singer DE, Hankey GJ, Breithardt G, Fox KAA, Califf. Print Publication – Journal of the American College of Cardiology (JACC)

• High-Grade Atrioventricular Block in Acute Coronary Syndromes: Insights from the Global Registry of Acute Coronary Events
  Singh SM, FitzGerald G, Yan AT, Brieger D, Fox KAA, López-Sendón J, Yan RT, Eagle KA, Steg PG, Budaj A, Goodman SG. Print Publication –  European Heart Journal

• Reperfusion Strategies in Acute Coronary Syndromes
  Bagai A, Dangas GD, Stone GW, Granger CB.  Print Publication –  Circulation Research

• • Trends in Short- and Long-Term Survival Among Out-of-Hospital Cardiac Arrest Patients Alive at Hospital Arrival
    Wong MKY, Morrison LJ, Qiu F, Austin PC, Cheskes S, Dorian P, Scales DC, Tu JV, Verbeek PR, Wijeysundera HC, Ko DT. Print Publication –  Circulation

 

• • Association Between Influenza Vaccination and Cardiovascular Outcomes in High-Risk Patients: A Meta-analysis
    Udell JA, Zawi R, Bhatt DL, Keshtkar-Jahromi M, Gaughran F, Phrommintikul A, Ciszewski A, Vakili H, Hoffman EB, Farkouh ME, Cannon CP.  Print Publication – Journal of the American Medical Association (JAMA)

 

• Association Between Physician Follow-Up and Outcomes of Care After Chest Pain Assessment in High-Risk Patients
  Czarnecki A, Chong A, Lee DS, Schull MJ, Tu JV, Lau C, Farkouh ME, Ko DT. Print Publication – Circulation

• Factors Associated With Thrombotic Complications After the Fontan Procedure: A Secondary Analysis of a Multicenter, Randomized Trial of Primary Thromboprophylaxis for 2 Years After the Fontan Procedure
  McCrindle BW, Manlhiot C, Cochrane A, Roberts R, Hughes M, Szechtman B, Weintraub R, Andrew M, Monagle P.  Print Publication – Journal of the American College of Cardiology

• A Glucagon-Like Peptide-1 Analog Reverses the Molecular Pathology and Cardiac Dysfunction of a Mouse Model of Obesity
  Noyan-Ashraf MH, Shikatani EA, Schuiki I, Mukovozov I, Wu J, Li R-K, Volchuk A, Robinson LA, Billia F, Drucker DJ, Husain M. Print Publication – Circulation

• Long-Term Cardiovascular Risk in Women Prescribed Fertility Therapy
  Udell JA, Lu H, Redelmeier DA. Print Publication – Journal of the American College of Cardiology (JACC)

• Phosphodiesterase Type 3A Regulates Basal Myocardial Contractility Through Interacting With Sarcoplasmic Reticulum Calcium ATPase Type 2a Signaling Complexes in Mouse Heart
  Beca S, Ahmad F, Shen W, Liu J, Makary S, Polidovitch N, Sun J, Hockman S, Chung YW, Movsesian M, Murphy E, Manganiello V, Backx PH. Print Publication – Circulation Research

• Preserving Prostaglandin E2 Level Prevents Rejection of Implanted Allogeneic Mesenchymal Stem Cells and Restores Postinfarction Ventricular Function
  Dhingra S, Li P, Huang X-P, Guo J, Wu J, Mihic A, Li S-H, Zang W-F, Shen D, Weisel RD, Singal PK, Li R-K. Print Publication – Circulation

• Prevalence and Extent of Obstructive Coronary Artery Disease Among Patients Undergoing Elective Coronary Catheterization in New York State and Ontario
  Ko DT, Tu JV, Austin PC, Wijeysundera HC, Samadashvili Z, Guo H, Cantor WJ, Hannan EL.  Print Publication – Journal of the American Medical Association (JAMA)

• Renal Hemodynamic Effect of Sodium-Glucose Cotransporter 2 Inhibition in Patients With Type 1 Diabetes Mellitus
  Cherney DZI, Perkins BA, Soleymanlou N, Maione M, Lai V, Lee A, Fagan NM, Woerle HJ, Johansen OE, Broedl UC, von Eynatten M. Print Publication – Circulation

• Risk Factor Control for Coronary Artery Disease Secondary Prevention in Large Randomized Trials
  Farkouh ME, Boden WE, Bittner V, Muratov V, Hartigan P, Ogdie M, Bertolet M, Mathewkutty S, Teo K, Maron DJ, Sethi SS, Domanski M, Frye RL, Fuster V. Print Publication – Journal of the American College of Cardiology (JACC)

• Survival After Implantable Cardioverter-Defibrillator Implantation in the Elderly
  Yung D, Birnie D, Dorian P, Healey JS, Simpson CS, Crystal E, Krahn AD, Khaykin Y, Cameron D, Chen Z, Lee DS. Print Publication – Circulation

• Temporal Differences in Out-of-Hospital Cardiac Arrest Incidence and Survival
  Bagai A, McNally BF, Al-Khatib SM, Myers JB, Kim S, Karlsson L, Torp-Pedersen C, Wissenberg M, van Diepen S, Fosbol EL, Monk L, Abella BS, Granger CB, Jollis JG. Print Publication – Circulation

• Lack of microsomal prostaglandin e2 synthase-1 in bone marrow-derived myeloid cells impairs left ventricular function and increases mortality after acute myocardial infarction. 
  Degousee N, Simpson J, Fazel S, Scholich K, Angoulvant D, Angioni C, Schmidt H, Korotkova M, Stefanski E, Wang XH, Lindsay TF, Ofek E, Pierre S, Butany J, Jakobsson PJ, Keating A, Li RK, Nahrendorf M, Geisslinger G, Backx PH, Rubin BB. View Publication

• Proximal Cerebral Arteries Develop Myogenic Responsiveness in Heart Failure via Tumor Necrosis Factor-α-Dependent Activation of Sphingosine-1-Phosphate Signaling.
  Yang J, Hossein Noyan-Ashraf M, Meissner A, Voigtlaender-Bolz J, Kroetsch JT, Foltz W, Jaffray D, Kapoor A, Momen A, Heximer SP, Zhang H, van Eede M, Henkelman RM, Matthews SG, Lidington D, Husain M, Bolz SS. View Publication

• Tumor necrosis factor-α-mediated downregulation of the cystic fibrosis transmembrane conductance regulator drives pathological sphingosine-1-phosphate signaling in a mouse model of heart failure.
  Meissner A, Yang J, Kroetsch JT, Sauvé M, Dax H, Momen A, Noyan-Ashraf MH, Heximer S, Husain M, Lidington D, Bolz SS. View Publication

• The CXCR4/CXCR7/SDF-1 pathway contributes to the pathogenesis of Shiga toxin-associated hemolytic uremic syndrome in humans and mice.
  Petruzziello-Pellegrini TN, Yuen DA, Page AV, Patel S, Soltyk AM, Matouk CC, Wong DK, Turgeon PJ, Fish JE, Ho JJ, Steer BM, Khajoee V, Tigdi J, Lee WL, Motto DG, Advani A, Gilbert RE, Karumanchi SA, Robinson LA, Tarr PI, Liles WC, Brunton JL, Marsden PA. View Publication

• Current perspectives on coronary chronic total occlusions: the Canadian Multicenter Chronic Total Occlusions Registry.
  Fefer P, Knudtson ML, Cheema AN, Galbraith PD, Osherov AB, Yalonetsky S, Gannot S, Samuel M, Weisbrod M, Bierstone D, Sparkes JD, Wright GA, Strauss BH. View Publication

• Derivation, expansion and differentiation of induced pluripotent stem cells in continuous suspension cultures.
  Fluri DA, Tonge PD, Song H, Baptista RP, Shakiba N, Shukla S, Clarke G, Nagy A, Zandstra PW. View Publication

• Risk, clinical features, and outcomes of thrombosis associated with pediatric cardiac surgery.
  Manlhiot C, Menjak IB, Brandão LR, Gruenwald CE, Schwartz SM, Sivarajan VB, Yoon H, Maratta R, Carew CL, McMullen JA, Clarizia NA, Holtby HM, Williams S, Caldarone CA, Van Arsdell GS, Chan AK, McCrindle BW. View Publication

• Epidermal growth factor-like domain 7 is a novel inhibitor of neutrophil adhesion to coronary artery endothelial cells injured by calcineurin inhibition.
  Badiwala MV, Guha D, Tumiati L, Joseph J, Ghashghai A, Ross HJ, Delgado DH, Rao V. View Publication

• Cardiovascular safety and diabetes drug development.
  Drucker DJ, Goldfine AB. View Publication

• Association of myocardial enzyme elevation and survival following coronary artery bypass graft surgery.
  Domanski MJ, Mahaffey K, Hasselblad V, Brener SJ, Smith PK, Hillis G, Engoren M, Alexander JH, Levy JH, Chaitman BR, Broderick S, Mack MJ, Pieper KS, Farkouh ME. View Publication

• The primary benefits of angiotensin-converting enzyme inhibition on cardiac remodeling occur during sleep time in murine pressure overload hypertrophy.
  Martino TA, Tata N, Simpson JA, Vanderlaan R, Dawood F, Kabir MG, Khaper N, Cifelli C, Podobed P, Liu PP, Husain M, Heximer S, Backx PH, Sole MJ. View Publication

• Plasma renin activity predicts cardiovascular mortality in the Heart Outcomes Prevention Evaluation (HOPE) study.
  Verma S, Gupta M, Holmes DT, Xu L, Teoh H, Gupta S, Yusuf S, Lonn EM. View Publication

• Sphingosine-1-phosphate-dependent activation of p38 MAPK maintains elevated peripheral resistance in heart failure through increased myogenic vasoconstriction.
  Hoefer J, Azam MA, Kroetsch JT, Leong-Poi H, Momen MA, Voigtlaender-Bolz J, Scherer EQ, Meissner A, Bolz SS, Husain M. Circ Res. 2010 Oct 1;107(7):923-33. Epub 2010 Jul 29. View Publication
• Effectiveness of public report cards for improving the quality of cardiac care: the EFFECT study: a randomized trial.
  Tu JV, Donovan LR, Lee DS, Wang JT, Austin PC, Alter DA, Ko DT  View Publication

• Routine early angioplasty after fibrinolysis for acute myocardial infarction.
  Cantor WJ, Fitchett D, Borgundvaag B, Ducas J, Heffernan M, Cohen EA, Morrison LJ, Langer A, Dzavik V, Mehta SR, Lazzam C, Schwartz B, Casanova A, Goodman SG; TRANSFER-AMI Trial Investigators.  View Publication

• GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice.
  Noyan-Ashraf MH, Momen MA, Ban K, Sadi AM, Zhou YQ, Riazi AM, Baggio LL, Henkelman RM, Husain M, Drucker DJ  View Publication

• Discoidin domain receptor 1 on bone marrow-derived cells promotes macrophage accumulation during atherogenesis.
  Franco C, Britto K, Wong E, Hou G, Zhu SN, Chen M, Cybulsky MI, Bendeck MP  View Publication

• Survival and cardiac remodeling after myocardial infarction are critically dependent on the host innate immune interleukin-1 receptor-associated kinase-4 signaling: a regulator of bone marrow-derived dendritic cells.
  Maekawa Y, Mizue N, Chan A, Shi Y, Liu Y, Dawood S, Chen M, Dawood F, de Couto G, Li GH, Suzuki N, Yeh WC, Gramolini A, Medin JA, Liu PP  View Publication

• Stem cell factor receptor induces progenitor and natural killer cell-mediated cardiac survival and repair after myocardial infarction.
  Ayach, B. B., Yoshimitsu, M., Dawood, F., Sun, M., Arab, S., Chen, M., Higuchi, K., Siatskas, C., Lee, P., Lim, H., Zhang, J., Cukerman, E., Stanford, W. L., Medin, J. A. and Liu, P. P.  View Publication

• Cardiac-specific overexpression of sarcolipin in phospholamban null mice impairs myocyte function that is restored by phosphorylation.
  Gramolini, A. O., Trivieri, M. G., Oudit, G. Y., Kislinger, T., Li, W., Patel, M. M., Emili, A., Kranias, E. G., Backx, P. H. and Maclennan, D. H..  View Publication

• Continuous positive airway pressure for central sleep apnea and heart failure.
  Bradley, T. D., Logan, A. G., Kimoff, R. J., Series, F., Morrison, D., Ferguson, K., Belenkie, I., Pfeifer, M., Fleetham, J., Hanly, P., Smilovitch, M., Tomlinson, G. and Floras, J. S.  View Publication

• The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient.
  Costantini, D. L., Arruda, E. P., Agarwal, P., Kim, K. H., Zhu, Y., Zhu, W., Lebel, M., Cheng, C. W., Park, C. Y., Pierce, S. A., Guerchicoff, A., Pollevick, G. D., Chan, T. Y., Kabir, M. G., Cheng, S. H., Husain, M., Antzelevitch, C., Srivastava, D., Gross,Design G. J., Hui, C. C., Backx, P. H. and Bruneau, B. G.  View Publication

• A randomized comparison of radial-artery and saphenous-vein coronary bypass grafts.
  Desai, N. D., Cohen, E. A., Naylor, C. D. and Fremes, S. E.  View Publication

• Global survey of organ and oranelle protein expression in mouse: combined proteomic and transcriptomic profiling.
  Kislinger, T., Cox, B., Kannan, A., Chung, C., Hu, P., Ignatchenko, A., Scott, S. S., Gramolini, A. O., Morris, Q., Hallett, M. T., Rossant, J., Hughes, T. R., Frey, B. and Emili, A.  View Publication

• Baf60c is essential for function of BAF chromatin remodelling complexes in heart development.
  Lickert, H., Takeuchi, J. K., Von Both, I., Walls, J. R., McAuliffe, F., Adamson, S. L., Henkelman, R. M., Wrana, J. L., Rossant, J. and Bruneau, B. G..  View Publication

• Impracticability of informed consent in the Registry of the Canadian Stroke Network.
  Tu, J. V., Willison, D. J., Silver, F. L., Fang, J., Richards, J. A., Laupacis, A. and Kapral, M. K..  View Publication