Network for Innovation in Clinical Research (NICR)

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Network for Innovation in Clinical Research (NICR)

Network for Innovation in Clinical Research (NICR)

In 2010, the University of Toronto cardiovascular clinical trials initiative was announced. The purpose of this initiative was to conduct single and multi-centre trials under the leadership of the University of Toronto cardiovascular clinical investigators. As a result of these early discussions, a more comprehensive network was proposed whereby all parties involved in cardiovascular clinical research at the University work together on important grant funded and industry-sponsored initiatives. Objectives of NICR include:
  1. To create a network whereby investigator-initiated or sponsor-initiated clinical research could be proposed by any of the member organizations and these initiatives would involve all pertinent parties within the University of Toronto network.
  2. To utilize the available resources and expertise at the University of Toronto to help support these initiatives. The core facilities would include: data management and statistical core; core lab facilities for electrocardiographic, MRI, CT and ECG; events adjudication committees; data safety monitoring committees; continuing medical education and educational activities revolving around research initiatives and novel devices and drugs; and fellowships and advanced training for house staff and junior faculty in clinical investigation.
  3. To promote the network’s activities on an international level using the combined resources of our member organizations.
  4. To reach out to international partners through an international NICR initiative.

Member organizations

The Department of Medicine and Cardiology Divisional Director; The University of Toronto Division of Cardiovascular Surgery; The Division of Vascular Surgery; The Peter Munk Cardiac Centre; The Applied Health Research Centre of the Li Ka Shing Knowledge Institute of St. Michael’s Hospital; The Canadian Heart Research Centre; University of Toronto Teaching Hospitals (Sunnybrook, UHN, St. Michael’s, Mount Sinai and the Hospital for Sick Children) ; Institute for Clinical Evaluation Sciences; The Heart & Stroke / Richard Lewar Centre of Excellence; and Greater Toronto Area Cardiologists.

Ongoing Clinical Trials

Ongoing Clinical Trials

Members of NICR are currently involved and recruiting in numerous local, multi-centre and multi-national clinical trials. These include testing novel drugs or strategies of care to reduce cardiovascular (CV) risk in patients across the spectrum of atherosclerosis and other CV disease (CVD). To have your trial included in this list, please contact Liz Thuo at liz.thuo@utoronto.ca. PATIENTS AT RISK FOR ISCHEMIC HEART DISEASE:
  1. ECAD (Eliminate Coronary Disease Study)
    • The purpose of this study is to determine whether pharmacologic lowering of low density lipoprotein cholesterol (LDL), initiated in healthy young to middle aged adults can eliminate or markedly reduce the composite endpoint of incident all cause mortality, myocardial infarction, stroke or coronary revascularization (low-dose statin versus standard care in patients with low Framingham Risk for IHD).
    • First Canadian Site: single centre pilot RCT located in Sudbury, Ontario
    • Investigators: Michael Farkouh (co-PI), Michael Domanski (co-PI), Jacob Udell
    • Randomized the first patient in September of 2014
    • http://clinicaltrials.gov/ct2/show/NCT02245087
  1. PISCES (Protection against Incidences of Serious Cardiovascular Events Study)
    • Randomized controlled trial evaluating the effect of fish oil supplementation on important health outcomes in the dialysis population (fish oil versus placebo in patients with chronic kidney disease)
    • Investigator: Charmaine Lok
    • http://www.isrctn.com/ISRCTN00691795
  1. TOSCA-5 (Total Occlusion Study in Coronary Arteries – 5)
    • A 2-stage study to evaluate single doses of MZ-004 at different dose levels in patients with chronic total occlusions
    • Principal Investigator: Christopher Buller
    • Principal Site investigator; Harindra Wijeysundera
    • Co-investigators: Neill Brass, Alexander Dick, Vladimir Dzavik, Anthony Fung, Lorne Goldman, John Graham, Jose Henriques, Jaroslav Hubacek, Sanjit Jolly, Samer Mansour, Stephane Rinfret, Erick Schampaert, Patrick Teefy, Rene van der Schaaf
    • Sponsor: Matrizyme Pharma Corporation
    • https://clinicaltrials.gov/ct2/show/NCT01753180
PATIENTS WITH STABLE ISCHEMIC HEART DISEASE (SIHD):
  1. ISCHEMIA (International Study of Comparative Health Effectiveness With Medical and Invasive Approaches)
    • Optimal medical therapy versus coronary angiography/revascularization strategy for patients with CHD and moderate-to-severe ischemia (ischemic guided vs medical therapy)
    • Sponsored by the NIH
    • Global Chair: Judith Hochman (NYU) and Global co-PI David Maron (Stanford)
    • Canadian National Coordinators/Steering Committee Members: Vlad Dzavik, Gilbert Gosselin, and Shaun Goodman
    • Local Investigators: Amar Uxa at UHN; Asim Cheema at St. Michael’s Hospital; Jacob Udell at WCH; John Parker at Mt. Sinai Hospital
    • ISCHEMIA CKD (Chronic Kidney Disease; Canadian National Leaders Ron Wald and Akshay Bagai) and CIAO-ISCHEMIA (Changes in ischemia and angina over one year among ISCHEMIA trial screen failures with no obstructive coronary artery disease on CT angiography) now funded and recruiting patients
    • Patient enrollment in the trial: Please page Ms. Susan Webber at Women's College Hospital at (416) 715-3706
    • http://clinicaltrials.gov/show/NCT01471522
  1. CAMELLIA-TIMI 61 (A Study to Evaluate the Effect of Long-term Treatment With BELVIQ (Lorcaserin HCl) on the Incidence of Major Adverse Cardiovascular Events and Conversion to Type 2 Diabetes Mellitus in Obese and Overweight Subjects With Cardiovascular Disease or Multiple Cardiovascular Risk Factors)
    • RCT of locaserin (selective serotonin agonist) versus placebo to reduce CV events in patients with type 2 diabetes mellitus with or at risk of CVD
    • Global Chair: Marc Sabatine; PIs: Steve Wiviott, Ben Scirica (TIMI Group, BWH)
    • Canadian Steering Committee Member: Larry Leiter (SMH)
    • Local Investigators: Jacob Udell at WCH
    • Patient enrollment in the trial: Please page Ms. Susan Webber at Women's College Hospital at (416) 715-3706
    • http://clinicaltrials.gov/show/NCT02019264
  1. CIRT (Cardiac Inflammation Reduction Trial)
    • RCT of low-dose methotrexate versus placebo in patients with type 2 diabetes mellitus or metabolic syndrome and SIHD
    • Global Chair: Paul Ridker (BWH)
    • Sponsored by NIH
    • Local Investigators: Jacob Udell at WCH
    • Toronto sites: WCH, St. Mike’s, Sunnybrook
    • Patient enrollment in the trial: Please page Ms. Susan Webber at Women's College Hospital at (416) 715-3706
    • http://clinicaltrials.gov/show/NCT01594333
ACUTE CORONARY SYNDROME (ACS):
  1. EMPRES (Exenatide for Myocardial Protection During Reperfusion Study)
    • This study aims to assess the effect of exenatide on myocardial injury in patients undergoing emergent percutaneous coronary intervention (PCI) for ST segment elevation myocardial infarction or heart attack (STEMI).
    • Study Chair and Principal Investigator: Vladimir Dzavik, University Health Network
    • Co-Investigators: Mansoor Husain, Christopher Overgaard
    • Study Coordination Centre: Applied Health Research Centre (AHRC)
    • Toronto sites: University Health Network, St Michael’s Hospital, Sunnybrook HSC
    • Other Canadian sites: Quebec City, Calgary, Hamilton, London, Edmonton, Newmarket
    • https://clinicaltrials.gov/ct2/show/NCT01938235
  1. TAILOR PCI (Tailored Antiplatelet Therapy Following PCI)
    • Study on tailored antiplatelet therapy using point-of-care genetic testing of clopidogrel metabolism in patients with ACS or PCI
    • Toronto sites: Toronto General Hospital (Chris Overgaard), St. Michael’s Hospital (John Graham), Sunnybrook Hospital (Mina Madan)
    • Other sites: Mayo sites (Rochester, Arizona, Phoenix), Ottawa, Korea
    • Steering Committee Members: Michael Farkouh, Shaun Goodman
    • Enrolled >1500 patients to date
    • http://clinicaltrials.gov/show/NCT01742117
  1. ASSIST Trial
    • Study of same-sitting non-culprit stenosis PCI during index primary PCI for STEMI
    • Toronto Site: St. Michael’s Hospital
    • Investigators: Michael Farkouh, Akshay Bagai, Asim N. Cheema
  1. CRIC-RCT (Chronic Remote Ischemic Conditioning Following Primary Percutaneous Intervention for ST-Elevated Myocardial Infarction
    • A preliminary study to see if daily RIC can help heart muscle recovery after a heart attack
    • Principal Investigators: Andrew Redington, SickKids; Christopher Overgaard, UHN
    • Co-Investigators: Harindra Wijeysundera, Micheal Farkouh, Alan Barolet, Andrew Crean, Paul Daly, Vladimir Dzavik, Eric Horlick, Douglas Ing, Mark Osten, Peter Seidelin, Matthew Sibbald
    • Principal Site investigator: Harindra Wijeysundera
    • Toronto sites: St. Michael's Hospital, UHN-Toronto General Hospital; Sunnybrook Health Sciences Centre; Hospital for Sick Children
    • https://clinicaltrials.gov/ct2/show/NCT01817114
STABILIZED FOLLOWING ACS:
  1. ODYSSEY Outcomes
    • Study of Alirocumab (PCSK9 inhibitor) versus placebo in post-ACS patients on maximally tolerated atorvastatin or rosuvastatin
    • Toronto site: St. Michael’s Hospital
    • Other sites: international
    • Investigators: Greg Schwartz and Gabriel Steg (Co-Chairs); Beth Abramson (St. Michael’s); Shaun Goodman (National Coordinator and Executive Steering Committee member)
    • http://clinicaltrials.gov/ct2/show/NCT01663402?term=4.%09ODYSSEY&rank=2
HEART FAILURE:
  1. ADVENT-HF: Effect of Adaptive Servo Ventilation (ASV) on Survival and Hospital Admissions in Heart Failure
    • Purpose of trial is to determine whether treating moderate or severe obstructive or central sleep apnea when present in heart failure patients with reduced systolic function reduces a composite endpoint of transplant-free survival and hospitalizations
    • Canadian Institutes of Health Research/SME Collaborative Research Program—Randomized Controlled Trials in Partnership with Respironics Inc.
    • Sponsored by: CIHR
    • Principal investigator: Doug Bradley, UHN
    • Co-investigators: John Floras, UHN/MSH, Sandy Logan UHN/MSH
    • Global chair: Doug Bradley
    • Toronto sites: UHN, Mount Sinai Hospital, St. Michael’s
    • Other sites: 40 sites, in Canada, US, Brazil, Spain, Italy, Germany, UK
    • Patient enrollment in the trial: Janis Andrews is Project Manager: (416) 597 3422 x 7805, Fiona Rankin is contact for UHN/MSH (416) 597 3422 x 3659 (UHN global address email), Doug Bradley, John Floras, Diego Delgado can also be contacted directly
    • https://clinicaltrials.gov/ct2/show/NCT01128816
  1. EMBRACE-MRI Study
    • Multi-center study examining myocardial tissue characterization by cardiac MRI to identify early cardiac toxicity during cancer therapy in women with breast cancer (cardiac MRI versus standard care surveillance).
    • Study centres: St. Michael’s Hospital, Sunnybrook Health Sciences Centre, and University Health Network
    • Principal Investigators: P. Thavendiranathan (PI), Bernd Wintersperger (Co-PI)
    • Co-investigators: Raymond Yan, Christine Brezden, Sunil Verma, Shaheeda Ahmed, Jacob A. Udell, Eitan Amir, Philippe Bedard, Marshall Sussman
  1. PARAGON-HF
    • RCT of LCZ696 (combined neprilysin inhibitor plus valsartan) versus valsartan to reduce CV events in patients with heart failure with preserved ejection fraction (HFpEF)
    • Global Chairs/co-PIs: Scott Solomon (BWH) and John J.V. McMurray (University of Glasgow, Scotland)
    • Local Investigators: Jacob Udell at WCH
    • Patient enrollment in the trial: Please page Ms. Susan Webber at Women's College Hospital at (416) 715-3706
    • http://clinicaltrials.gov/show/NCT01920711
  1. MITNEC B5: (Non-Isotope Based Imaging Modalities vs 99mTc SPECT MPI to Detect Myocardial Ischemia in Patients at High Risk for Ischemic Cardiovascular Events)
    • Objective: To compare the accuracy of 99mTc SPECT with the accuracy of CMR, CT and stress echocardiography in patients with symptoms suggestive of myocardial ischemia who are at high risk for ischemic cardiovascular events.
    • Principal Investigator: Jean-Claude Tardif
    • Local investigators: Howard Leong-Poi and Kim Connelly
    • https://clinicaltrials.gov/ct2/show/NCT01972360
  1. IMAGE-HF Project I-A: Cardiac Imaging in Ischemic Heart Failure (AIMI-HF)
    • The overall objectives of the IMAGE-HF trial are 1) to determine the impact of emerging imaging strategies, on relevant clinical outcomes and decision making in patients with HF; 2) to establish standardization quality assurance measures and central databases in order to achieve reliable outcome driven research; 3) to apply this as a platform for evaluation of new and emerging imaging biomarkers in HF.
    • Project I-A: The primary objective of AIMI-HF is to compare the effect of HF imaging strategies on the composite clinical endpoint of cardiac death, myocardial infarction (MI), arrest and cardiac re-hospitalization (worsening heart failure (WHF), acute coronary syndrome (ACS), arrhythmia). Patients with an ischemic heart disease (IHD) etiology will follow HF imaging strategy algorithms according to the question(s) asked by the physicians (is there ischemia and/or viability), in agreement with their local practices for standard and alternative imaging.
    • Principal Investigator: Kim Connelly, St. Michael’s Hospital; and Graham Wright, Sunnybrook Health Sciences Centre
    • Toronto Sites: St. Michael’s Hospital and Sunnybrook Health Sciences Centre
    • https://clinicaltrials.gov/ct2/show/NCT01288560
APPROPRIATENESS:
  1. Echo-WISELY (Will Inappropriate Scenarios for Echocardiography Lessen Significantly in an Educational RCT)
    • International, prospective, multi-centred, investigator blinded, randomized control trial of an educational and feedbackbased intervention vs. usual care to study the proportion of inappropriate TTEs ordered by clinicians (Cardiology and GIM/PCP) in ambulatory care.
    • Toronto Sites: Women’s College Hospital, Sunnybrook Health Sciences Centre, Mount Sinai Hospital, St Michael’s Hospital, UHN (TWH and TGH)
    • Other sites: Kingston General Hospital, Brigham and Women’s and Massachusetts General Hospital
ELECTROPHYSIOLOGY (EP):
  1. TOUCH AF: (Therapeutic Outcomes Using Contact Force Handling During Atrial Fibrillation Ablation)
    • The purpose of this study is to compare two strategies of wide antral pulmonary veins isolation plus linear ablation for persistent atrial fibrillation: 1) guided by contact force sensing, or 2) blinded to contact force sensing - i.e. standard approach
    • Lead Investigator: Atul Verma, Southlake Regional Health Centre
    • Study Coordination Centre: Applied Health Research Centre (AHRC)
    • https://clinicaltrials.gov/ct2/show/study/NCT01851525
  1. MARE Study: Ambulatory Electrocardiographic Monitoring for the Detection of High-Degree Atrio-Ventricular Block in Patients with New-onset Persistent Left Bundle Branch Block After Transcatheter Aortic Valve Implantation
    • The purpose of this study is to determine the incidence and predictors of high degree or complete atrioventricular block (paroxysmal or persistent) in patients with new-onset persistent left bundle branch block (NOP-LBBB) following transcatheter aortic valve implantation (TAVI) and to evaluate the usefulness of the Reveal LINQ® insertable Cardiac Monitor for the detection of significant arrhythmias in patients with NOP-LBBB following TAVI.
    • Principal Investigator: Josep Rodes, MD IUCPQ
    • Principal Site investigator: Harindra Wijeysundera
    • Sponsor: Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec
    • https://clinicaltrials.gov/ct2/show/NCT02153307
CARDIO-MEDICAL:
  1. NEAT (Novel Endovascular Access Trial)
  1. SUCCOUR Trial (Strain Surveillance During Chemotherapy for Improving Cardiovascular Outcomes)
  1. TRICS-III (Transfusion Requirements in Cardiac Surgery III)
    • An international, multi-centre, open-label randomized controlled trial of two commonly used transfusion strategies in high risk patients having cardiac surgery using a non-inferiority trial design.
    • Lead Investigators: David Mazer, St. Michael's Hospital; Nadine Shehata, Mount Sinai Hospital
    • Toronto sites: St. Michael's Hospital, Sunnybrook HSC
    • https://clinicaltrials.gov/ct2/show/NCT02042898
PERIPHERAL ARTERIAL DISEASE (PAD):
  1. BEST-CLI (Randomized, Multicenter, Controlled Trial to Compare Best Endovascular versus Best Surgical Therapy in Patients with Critical Limb Ischemia)
    • Purpose of trial is to evaluate the effectiveness of best endovascular (EVT) compared to best surgical (OPEN) revascularization in patients with CLI.
    • Principal investigator: Thomas Lindsay (University Health Network)
    • Co-investigators: Dr. KT Tan, Dr. Thomas Forbes, Dr. Graham Roche-Nagle, Dr. George Oreopoulos, Dr. Leonard Tse, Dr. John Byrne, Dr. Dheeraj Rajan, Dr. Ken Sniderman, Dr. Jeff Jaskolka, Dr. John Kachura, Dr. Robert Beecroft, Dr. Martin Simons
    • Global chair: Alik Farber
    • Toronto sites: University Health Network
    • Other sites: 120 centres in US and Canada
    • Funding sponsor: National Heart, Lung, and Blood Institute (NHLBI), USA
    • Patient enrollment in the trial: Please contact trial coordinator, Iris Zhong at iris.zhong@uhn.ca or (416) 946-4501 ext. 4816.
    • http://www.bestcli.com/
  1. A Randomized Double Blind Placebo-Controlled Clinical Study to Assess Blood-Borne Autologous Angiogenic Cell Precursors Therapy in Patients with Critical Limb Ischemia (ACP-CLI)
    • Purpose of trial: To determine the efficacy and safety of intramuscular injection of blood-borne autologous ACPs in relieving symptoms of critical limb ischemia in patients on standard of care therapy and with no endovascular or surgical revascularization option.
    • Principal investigator: Thomas Lindsay (University Health Network)
    • Co-investigators: Dr. KT Tan
    • Toronto sites: University Health Network and St. Michael’s hospital
    • Other sites: Vancouver General Hospital
    • Funding sponsor: Hemostemix Ltd.
    • Patient enrollment in the trial: Please contact trial coordinator, Iris Zhong at iris.zhong@uhn.ca or (416) 946-4501 ext. 4816.
    • https://clinicaltrials.gov/ct2/show/NCT02140931

Newsletter

Newsletter

NICR Newsletter - March 2015 - Download NICR Newsletter - October 2014 - Download

2015 Publications by NICR Members

2015 Publications by NICR Members

Sorted alphabetically by publication name
  1. Moe GW, Ezekowitz JA, O'Meara E, Lepage S, Howlett JG, Fremes S, Al-Hesayen A, Heckman GA, Abrams H, Ducharme A, Estrella-Holder E, Grzeslo A, Harkness K, Koshman SL, McDonald M, McKelvie R, Rajda M, Rao V, Swiggum E, Virani S, Zieroth S, Arnold JM, Ashton T, D'Astous M, Chan M, De S, Dorian P, Giannetti N, Haddad H, Isaac DL, Kouz S, Leblanc MH, Liu P, Ross HJ, Sussex B, White M. The 2014 Canadian Cardiovascular Society heart failure management guidelines focus update: anemia, biomarkers, and recent therapeutic trial implications. Can J Cardiol 2015 Jan;31(1):3-16. Epub 2014 Dec 19.
  2. Czarnecki A, Prasad T, Wang J, Wijeysundera HC, Cheema AN, Dz̆avík V, Natarajan MK, Simpson CS, So DY, Syed J, Tu JV, Ko DT. Adherence to Process of Care Quality Indicators after Percutaneous Coronary Intervention in Ontario, Canada: A Retrospective Observational Cohort Study. Open Heart. 2015 Jan 23. In Press.
  3. Mohareb MM, Qiu F, Cantor WJ, Kingsbury KJ, Ko DT, Wijeysundera HC. Appropriate Use Criteria and the Diagnostic Yield of Coronary Angiography. Annals of Internal Medicine. 2015 Jan 2. In Press.
  4. Yu EH, Nair P, Sibbald MG, Lee DS, Dorian P. Can diagnostic and procedural skills required to practice cardiology as a specialist be mastered in 3 years? Can J Cardiol 2015 Jan;31(1EH):91-4. Epub 2014 Nov 4.
  5. Tu JV, Chu A, Donovan LR, Ko DT, Booth GL, Tu K, Maclagan LC, Guo H, Austin PC, Hogg W, Kapral MK, Wijeysundera HC, Atzema CL, Gershon AS, Alter DA, Lee DS, Jackevicius CA, Bhatia RS, Udell JA, Rezai MR, Stukel TA. The Cardiovascular Health in Ambulatory Care Research Team (CANHEART): Using Big Data to Measure and Improve Cardiovascular Health and Healthcare Services. Circ Cardiovasc Qual Outcomes. 2015 Feb 3. 2015; Feb 3 [Epub ahead of print].
  6. Wael Abuzeid, Maria Bennell, Feng Qiu, Saleem Kassam, Chris Overgaard, Neil Fam, Harindra C. Wijeysundera. Clinical Outcomes of Early Repatriation for patients with ST-segment elevation Myocardial Infarction: A propensity-matched analysis. Canadian Journal of Cardiology. 2015 Jan 30. In Press.
  7. Notarius CF, Millar PJ, Murai H, Morris BL, Marzolini S, Oh P, Floras JS (2015). Divergent muscle sympathetic responses to dynamic leg exercise in heart failure and age-matched healthy subjects. Journal of Physiology 593:715-722.
  8. Connelly KA, Advani A, Zhang Y, Advani SL, Kabir G, Abadeh A, Desjardins JF, Mitchell M, Thai K, Gilbert RE. DPP-4 inhibition improves cardiac function in experimental myocardial infarction: Role of SDF-1 alpha. J Diabetes. 2015 Jan 7. Principal Author.
  9. Roifman I, Connelly KA, Wright GA, Wijeysundera HC. Echocardiography vs. Cardiac Magnetic Resonance Imaging for the Diagnosis of Left Ventricular Thrombus- A Systematic Review. Canadian Journal of Cardiology. 2015 Jan 20. In Press.
  10. Russo JJ, Goodman SG, Cantor WJ, Tan MK, Borgundvaag B, Fitchett D, Džavík V, Yan RT, Graham JJ, Mehta SR, Yan AT. Efficacy and Safety of a Routine Early Invasive Strategy in Relation to Time from Symptom Onset to Fibrinolysis (A Subgroup Analysis of TRANSFER-AMI). Am J Cardiol. 2015. In Press.
  11. Atzema CL, Yu B, Ivers N, Rochon P, Lee DS, Schull MJ, Austin PC. Incident atrial fibrillation in the emergency department: a population-based assessment of follow-up care. CMAJ Open 2015 [in press]
  12. Alnasser SMA, Huang W, Gore JM, Steg PG, Eagle KA, Anderson FA, Fox KAA, Gurfinkel E, Brieger D, Klein W, van de Werf F, Avezum A, Montalescot G, Gulba DC, Budaj A, Lopez-Sendon J, Granger CB, Kennelly BM, Goldberg RJ, Fleming E, Goodman SG, on behalf of the GRACE Investigators*. The Late Consequences of Acute Coronary Syndromes: 2-Year Follow-up Outcomes, Procedures, and Treatment of Patients from the Global Registry of Acute Coronary Events (GRACE). 2015. In Press.
  13. Zeidan-Shwiri T, Yang Y, Lashevsky I, Kadmin E, Kagal D, Dick A, Farkash AL, Paul G, Gao D, Shurrab M, Newman D, Wright G, Crystal E. Magnetic Resonance Estimates of the Extent and Heterogeneity of Scar Tissue in ICD patients with Ischemic Cardiomyopathy Predict Ventricular Arrhythmia. Heart Rhythm. Jan 2015: pii: S1547-5271(15)00008-9. doi: 10.1016/j.hrthm.2015.01.007. [Epub ahead of print]
  14. Amir Hanna, Kim A Connelly, Robert G Josse, and Roger S McIntyre. The non-glycemic effects of incretin therapies on cardiovascular outcomes, cognitive function and bone health. Endocrinology & Metabolism Journal. 2015 Jan;10(1):101-114. In Press. Coauthor or Collaborator.
  15. Millar PJ, Murai H, Floras JS (2015). Paradoxical muscle sympathetic reflex activation in human heart failure. Circulation 131:459-468.
  16. Sud M, Wang X, Austin PC, Lipscombe LL, Newton GE, Tu JV, Vasan RS, Lee DS. Presentation blood glucose and death, hospitalization, and future diabetes risk in patients with acute heart failure syndromes. Eur Hear J 2015 [Epub ahead of print]
  17. Merchant A, Wald R, Goldstein MB, Yuen D, Kirpalani A, Dacouris A, Ray JG, Kiaii M, Leipsic J, Kotha V, Deva D, Yan AT. Relationship between Different Blood Pressure Measurements and Left Ventricular Mass by Cardiac Magnetic Resonance Imaging in End-stage Renal Disease. Journal of the American Society of Hypertension. 2015. In Press.
  18. Madan M, Halvorsen S, Di Mario C, Tan M, Westerhout CM, Cantor WJ, Le May MR, Borgia F, Piscione F, Scheller B, Armstrong PW, Fernandez-Aviles F, Sanchez PL, Graham JJ, Yan AT, Goodman SG. Relationship Between Time to Invasive Assessment and Clinical Outcomes Among Patients Undergoing an Early Invasive Strategy After Fibrinolysis for ST-Elevation Myocardial Infarction: a Patient-level Analysis of the Randomized Early Routine Invasive Clinical Trials. JACC: Cardiovascular Interventions. 2015;8(1):166-74.
  19. Patel AD , Tan MK, Angaran P, Bell AD, Berall M, Bucci C, Demchuk AM, Essebag V, Goldin L, Green MS, Gregoire JC, Gross PL, Heilbron B, Lin PJ, Ramanathan K, Skanes A, Wheeler BH, Goodman SG. Risk Stratification and Stroke Prevention Therapy Care Gaps in Canadian Atrial Fibrillation Patients: Insights from the CO-ordinated National Network to Engage physicians in the Care and Treatment of patients with Atrial Fibrillation (CONNECT AF). Am J Cardiol. 2015. In Press.
  20. Yun H, Safford MM, Brown TM, Farkouh ME, Kent S, Sharma P, Kilgore M, Bittner V, Rosenson RS, Delzell E, Muntner P, Levitan EB. Statin use following hospitalization among medicare beneficiaries with a secondary discharge diagnosis of acute myocardial infarction. J Am Heart Assoc. 2015 Feb 9;4(2). pii: e001208. doi: 10.1161/JAHA.114.001208.
  21. McAlister FA, Wang J, Donovan L, Lee DS, Armstrong PW, Tu JV. The influence of alternate goals of care on comparisons of performance measures and quality metrics in patients hospitalized for heart failure – A secondary analysis of the EFFECT registry. Circulation: Heart Failure 2015 [in press]

2015 Abstracts by NICR Members

Sorted alphabetically by publication name
  1. Siu, L. Morikawa, A. Ramadeen, L. Zhang, J. Lau, G. Liu, M. Pop, T. Hu, K. Connelly, G.A. Wright. “Characterization of the ultra-short echo time magnetic resonance (UTE MR) collagen signal associated with myocardial fibrosis”. Poster presentation at SCMR/EuroCMR joint Scientific Sessions, February 6, 2015, Nice, France.
  2. Roifman, K. Connelly, G.A. Wright. “Comparison of a novel free breathing SSFP sequence with standard breath held SSFP – a pilot study”. Poster presentation at SCMR/EuroCMR joint Scientific Sessions, February 6, 2015, Nice, France.
  3. Roifman, K. Connelly, G.A. Wright. “Diabetes Mellitus is an Independent Predictor of Right Ventricular Dysfunction”. Poster presentation at SCMR/EuroCMR joint Scientific Sessions, February 6, 2015, Nice, France.
  4. N. Ghugre, N. Shie, X. Qi, M. Pop, J. Barry, B. Strauss, G.A. Wright. “Hemorrhage contributes to chronic adverse remodeling in acute myocardial infarction: Insights from a novel preclinical model”. Poster presentation at SCMR/EuroCMR joint Scientific Sessions, February 6, 2015, Nice, France.
  5. L. Zhang, G.A. Wright. “Improved Characterization of Infarct Heterogeneity from High Resolution T1* maps using Compressed Sensing and temporal PCA with Weighted Total Variation”. Poster presentation at SCMR/EuroCMR 2015 Workshop, February 6, 2015, Nice, France.
  6. T. Roy, G. Liu, X. Qi, A. Dueck, G.A. Wright. “MRI Characterization of peripheral arterial chronic total occlusions at 7 Tesla with microCT and histologic validation”. Poster presentation at SCMR/EuroCMR joint Scientific Sessions, February 6, 2015, Nice, France.
  7. H. Chen, G.A. Wright. “Physiological model for the interpretation of ASL-measured reactive hyperemia in leg muscles”. Abstract for non-contrast CMR Workshop 2015, March 6-8, 2015, Long Beach, CA, USA.
  8. M. Zia, N. Ghugre, I. Roifman, K. Connelly, A. Dick, G.A. Wright. “Prognostic Value of Myocardial T2 Mapping Post Reperfused Acute Myocardial Infarction”. Poster presentation at SCMR/EuroCMR 2015 Workshop, February 6, 2015, Nice, France.
  9. R. Xu, P. Athavale, P. Krahn, K. Anderson, J. Barry, M. Pop, L. Biswas, V. Ramanan, N. Yak, G.A.Wright. “Respiratory motion model based correction for improving the targeting accuracy of MRI-guided intracardiac electrophysiology procedures”. Oral abstract at SCMR/EuroCMR joint Scientific Sessions, February 6, 2015, Nice, France.
NOTE: We wish to regularly highlight NICR members’ achievements and welcome submissions. Please contact Tracey Richards at hsrl.centre@utoronto.ca so we can add yours.

2014 Publications by NICR Members

2014 Publications by NICR Members

Sorted alphabetically by publication name
  1. Canadian Cardiovascular Society Heart Failure Management Primary Panel: Moe GW, Ezekowitz JA, O'Meara E, Howlett JG, Fremes SE, Al-Hesayen A, Heckman GA, Ducharme A, Estrella-Holder E, Grzeslo A, Harkness K, Lepage S, McDonald M, McKelvie RS, Nigam A, Rajda M, Rao V, Swiggum E, Virani S, Van Le V, Zieroth S; Secondary Panel:, Arnold JM, Ashton T, D'Astous M, Dorian P, Giannetti N, Haddad H, Isaac DL, Kouz S, Leblanc MH, Liu P, Ross HJ, Sussex B, White M. The 2013 Canadian Cardiovascular Society Heart Failure Management Guidelines Update: focus on rehabilitation and exercise and surgical coronary revascularization. Can J Cardiol 2014 Mar;30(3):249-63. Epub 2013 Oct 19.
  2. Muntner P, Yun H, Sharma P, Delzell E, Kent ST, Kilgore ML, Farkouh ME, Vupputuri S, Bittner V, Rosenson RS, Levitan EB, Safford MM. Ability of low antihypertensive medication adherence to predict statin discontinuation and low statin adherence in patients initiating treatment after a coronary event. Am J Cardiol. 2014 Sep 15;114(6):826-31.
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  173. Lee PJ, Rudenko D, Kuliszewski MA, Liao C, Kabir MG, Connelly KA, Leong-Poi H. Surviving gene therapy attenuates left ventricular systolic dysfunction in doxorubicin cardiomyopathy by reducing apoptosis and fibrosis. Cardiovascular Research. 2014 Jan 8;101(3):423-33.
  174. Bagai A, Peterson ED, Honeycutt E, Effron MB, Cohen DJ, Goodman SG, Anstrom K, Gupta A, Messenger JC, Wang TY. Switching Between Oral ADP Receptor Inhibitors in Patients with Acute Myocardial Infarction Treated with Percutaneous Coronary Intervention: Insights to Contemporary Practice from the TRANSLATE-ACS Study. European Heart Journal - Acute Cardiovascular Care. 2014. 2014 Dec 16 Epub ahead of print. In Press.
  175. Lin S, Scales DC, Dorian P, Kiss A, Common MR, Brooks SC, Goodman SG, Salciccioli JD, Morrison LJ. Targeted temperature management processes and outcomes after out-of-hospital cardiac arrest: An observational cohort study. Critical Care Medicine 2014 Dec;42(12):2565-74. Epub 2014 Sep 3.
  176. Dunlop K, Gosal K, Kantores C, Ivanovska J, Dhaliwal R, Desjardins JF, Connelly KA, Jain A, McNamara PJ, Jankov RP. Therapeutic hypercapnia prevents inhaled nitric oxide-induced right-ventricular systolic dysfunction in juvenile rats. Free Radic Biol Med. 2014 Apr 1;69:35-49.
  177. Ahmed M, Azizi-Namini P, Yan AT, Keith M. Thiamin deficiency and heart failure: the current knowledge and gaps in literature. Heart Failure Reviews 2014 May 9 [Epub ahead of print]. In Press.
  178. Naylor KL, McArthur E, Leslie WD, Fraser LA, Jamal SA, Cadarette SM, Pouget JG, Lok CE, Hodsman AB, Adachi JD, Garg AX. The three-year incidence of fracture in chronic kidney disease. Kidney Int. 2014 Oct;86(4):810-8. doi: 10.1038/ki.2013.547. Epub 2014 Jan 15. PubMed PMID: 24429401.
  179. Ko DT, Wijeysundera H, Udell JA, Vaccarino V, Austin P, Gao H, Velianou J, Lau KA, Tu JV. Traditional cardiovascular risk factors and presence of obstructive coronary artery disease in men and women. Can J Card. 2014 Jul 1;30(7):820-26. (doi: 10.1016/j.cjca.2014.04.032). Impact Factor: 3.122; C
  180. Wong MK, Morrison LJ, Qiu F, Austin PC, Cheskes S, Dorian P, Scales DC, Tu JV, Verbeek PR, Wijeysundera HC, Ko DT. Trends in Short- and Long-Term Survival Among Out-of-Hospital Cardiac Arrest Patients Alive at Hospital Arrival. Circulation. 2014 Nov 18;130(21):1883-90.
  181. Yan AT, Gupta P, Deva D, Choi R, Kirpalani A. An Unusual Case of Metastatic Carcinoid Tumour in the Interventricular Septum (case report). Journal of Cardiovascular Medicine 2014 Jul 10 [Epub ahead of print]. In Press.
  182. Thavendiranathan P, Poulin F, Lim KD, Plana JC, Woo A, Marwick TH. Use of myocardial strain imaging by echocardiography for the early detection of cardiotoxicity in patients during and after cancer chemotherapy: a systematic review. J Am Coll Cardiol. 2014 Jul 1;63(25 Pt A):2751-68.
  183. Hingwala J, Bhola C, Lok CE. Using tunneled femoral vein catheters for “urgent start” dialysis patients: a preliminary report. J Vasc Access. 2014;15 Suppl 7:S101-8. doi: 10.5301/jva.5000252. Epub 2014 Apr 28. PubMed PMID: 24817465.
  184. Kumareswaran R, Dorian P. Utility of anti-arrhythmic medications in 'lone atrial fibrillation'. Curr Pharm Des 2014;21(5):573-9. Epub 2014 Aug 25
  185. Shariat M, Thavendiranathan P, Nguyen E, Wintersperger B, Paul N, Rakowski H, Crean AM. Utility of Coronary computed tomography angiography in outpatients with hypertrophic cardiomyopathy presenting with angina symptoms. Journal of Cardiovascular Computed Tomography. 2014 Sep 19. In Press.
  186. Singh SM, Webster L, Calzavara A, Wijeysundera HC. Validation of Algorithms to Identify Invasive Electrophysiology Procedures Using Administrative Data in Ontario, Canada. Med Care. 2014 Nov 20. In Press.
  187. Windram JD, Colman JM, Wald RM, Udell JA, Siu SC, Silversides CK. Valvular heart disease in pregnancy. Best Practice ObGyny 2014;28(4):507-18. Impact Factor: 2.016; C
  188. Drew DA, Lok CE, Cohen JT, Wagner M, Tangri N, Weiner DE. Vascular Access Choice in Incident Hemodialysis Patients: A Decision Analysis. J Am Soc Nephrol. 2014 Jul 25. pii: ASN.2013111236. [Epub ahead of print] PubMed PMID: 25063436.
  189. Levitt K, Vivas L, Courtney B, Connelly KA. Vascular imaging in diabetes. Curr Atheroscler Rep. 2014 Apr 1;16(4):399.
  190. Dorian P, Angaran P. β-Blockers and Atrial Fibrillation: Hypertension and other medical conditions influencing their use. Can J Cardiol 2014 May;30(5 Suppl):S38-41. Epub 2013 Oct 9.

2014 Abstracts by NICR Members

Sorted alphabetically by publication name
  1. Tan NS, Goodman SG, Cantor WJ, Tan M, Yan RT, Bagnall AJ, Mehta SR, Fitchett D, Strauss BH, Yan AT. Efficacy of Pharmacoinvasive Management for ST-Segment Elevation Myocardial Infarction in Relation to Smoking Status: A Subgroup Analysis of TRANSFER-AMI. Can J Cardiol. 2014;30(10S):S64.
  2. Stainsby G, Zhang L, Wright GA. Accelerated Myocardial T1 Mapping Using SMART1Map and Compressed Sensing with Temporal PCA. Oral Abstract at SCMR 2014, January 18, 2014, New Orleans, Louisianna, USA. Journal of Cardiovascular Magnetic Resonance 2014, 16(Suppl 1):O9.
  3. Hess CN, James S, Wojdyla DM, Lopes RD, Liaw D, Hagstrom E, Bhatt DL, Husted S, Goodman SG, Lewis BS, Verheugt FWA, De Caterina R, Ogawa H, Wallentin L, Alexander JH. Apixaban Plus Mono versus Dual Antiplatelet Therapy After Acute Coronary Syndromes: Insights from the APPRAISE-2 Trial. Circulation. 2014. Circ 2014;in press. In Press.
  4. Ghugre N, Thomas R, Thai K, Barry J, Qiang B, Strauss B, Wright GA. Area at risk identified by T2 mapping is influenced by the severity of the initial ischemic insult in acute myocardial infarction. E-Poster#7233 at ISMRM 2014, May 13, 2014, Milan, Italy.
  5. Quadros KK, Coomes E, Bajaj RR, Finken LR, Wharieff W, Bagai A, Mehdi NB, Cheema AN. Awareness of Cardiovascular risk Factors among Immigrants and Non-Immigrants in Canada – A Survey Study. Can J Cardiol. 2014 Oct;30(10):S 133. Highlighted Poster Presentation. CCC 2014, Vancouver Oct 25-28, 2014.
  6. Dery JP, Fisher HN, Qin Y, Zhu YE, Huynh T, Welsh RC, Quraishi A, Schampaert E, Mehta SR, Goodman SG. Bleeding and Ischemic Events in Canadian Patients with Myocardial Infarction Undergoing Percutaneous Coronary Intervention: Insights from the Canadian Observational Antiplatelet Study (COAPT) at 1 Year. Can J Cardiol. 2014. In press. In Press.
  7. Negishi T, Negishi K, Hristova K, Kurosawa K, Yuda S, Popescu BA, Vinereanu D, Thavendiranathan P, Penicka M, Bansal M, Fukuda N, Cho GY, Seldrum S, Marwick TH. Calibration and Feedback of Speckle Strain Measurement Improves Segmental Strain Concordance. American Heart Association Scientific Sessions, 2014.
  8. G. Liu, G.A. Wright. Cardiac Gating Calibration by the MR Septal Scout. E-Poster# 5176 at ISMRM 2014, May 13, 2014, Milan, Italy.Venkat Ramanan, Mohammad Zia, Idan Roifman, Bradley H Strauss, Kim Connelly, Nilesh Ghugre, Graham A. Wright. Microvascular obstruction is associated with greater extracellular matrix remodeling in the remote myocardium after infarction: A T1-mapping study. Traditional Poster# 7568 at ISMRM 2014, May 14, 2014, Milan, Italy.
  9. Quadros KK, Coomes E, Bajaj RR, Finken LR, Sharieff W, Bagai A, Mehdi NB, Cheema AN. Cardiovascular risk factor awareness among recent immigrants: A population based study. JACC. 2014 Apr 1;63(12 _Suppl1):A1420. Poster Presentation. ACC 2014, Washington D.C., March 29 – 31, 2014.
  10. Quadros KK, Coomes E, Bajaj RR, Finken LR, Sharieff W, Bagai A, Mehdi ND, Cheema AN. Cardiovascular Risk Factor Awareness and Prevalence among Canadian Men and women – does Gender Play a Role? A Population-Based Survey Analysis. Can J Cardiol. 2014 Oct;30(10):S 86. Poster Presentation. CCC 2014. Vancouver Oct 25-28, 2014.
  11. Abuzeid W, Bennell M, Qiu F, Kassam S, Overgaard C, Fam N, Wijeysundera HC. Clinical Outcomes of Early Repatriation for Patients with ST-Segment Elevation Myocardial Infarction: A Propensity-Matched Analysis. Canadian Journal of Cardiology. 2014 Oct 1;30(10 Suppl):S66–S67. Presentation at the Canadian Cardiovascular Congress (CCC) 2014 in Vancouver, British Columbia, October 25-28, 2014 (Trainee publication).
  12. Tran C, Wijeysundera H, Qui F, Tu JV, Bhatia R. Comparing the ambulatory care and outcomes for rural and urban patients with chronic ischemic heart disease: a population-based cohort study. Canadian Journal of Cardiology. 2014 Oct 1;30(10 Suppl):S74.
  13. Bennell MC, Qiu F, Kingsbury KJ, Austin PC, Wijeysundera HC. Determinants of the Variation in Practice Patterns for Revascularization versus Medical Therapy in Stable Ischemic Heart Disease – A Population Based Study. J Am Coll Cardiol. 2014 Apr 1;63(12_S):A1620. Poster presentation at the American College of Cardiology 63rd Annual Scientific Session and TCT@ACC-i2, Saturday, March 29-Monday, March 31, 2014, in Washington, DC, USA.
  14. Xiuling Qi, Benu Sethi, Mihaela Pop, Jennifer Barry, Sudip Ghate, Eugene Crystal, Graham Wright. Determination of the characteristics of thermal ablation lesions in rabbit muscle by MRI and histology. Poster at IMNO 2014, March 24, 2014, Toronto, Ontario, Canada.
  15. Hanneman K, Thavendiranathan P, Nguyen ET, Ward R, Jolly M, Yang IY, Sussman MS, Wintersperger BJ. Diffuse myocardial interstitial fibrosis assessed by cardiac MR: relationship to systolic and diastolic function in thalassemia Major. North American Society of Cardiovascular Imaging Annual Meeting, 2014.
  16. Roifman I, Rezai MR, Wijeysundera H; Chow B, Wright GA, Tu JV. Diffusion of Cardiac Computed Tomography Angiography and its Effect on Coronary Angiography in Ontario, Canada. J Am Coll Cardiol. 2014 Apr 1;63(12_S):A1261. Poster presentation at the American College of Cardiology 63rd Annual Scientific Session and TCT@ACC-i2, Saturday, March 29-Monday, March 31, 2014, in Washington, DC, USA.
  17. Russo JJ, Goodman SG, Cantor WJ, Tan M, Borgundvaag B, Fitchett D, Dzavik V, Yan RT, Graham JJ, Mehta SR, Yan AT. Efficacy and Safety of a Routine Early Invasive Strategy in Relation to Time From Symptom Onset to Fibrinolysis: A Subgroup Analysis from TRANSFER AMI. Can J Cardiol. 2014;30(10S):S147.
  18. Elbarouni B, Cantor WJ, Ducas J, Borgundvaag B, Dzavik V, Heffernan M, Buller CE, Langer A, Goodman SG, Yan AT. Efficacy of an Early Invasive Strategy Following Fibrinolysis in ST-Elevation Myocardial Infarction in Relation to the Angiographic Extent of Coronary Artery Disease. Can J Cardiol. 2014;30(10S):S63.
  19. Labonny Biswas, Akram Kassay, Kevan Anderson, Perry Radau, Graham Wright. Feasibility of gesture-based control of MRI-guided interventional procedures. E-Poster# 7511 at ISMRM 2014, May 12, 2014, Milan, Italy.
  20. Dehghani P, Rezael E, Sharieff W, Bagai A, Cheema AN. Feasibility of repeat ipsilateral transradial access for percutaneous coronary interventions. JACC. 2014 Apr 1;63(12 _Suppl1):A1804. Poster Presentation. ACC 2014, Washington D.C., March 29 – 31, 2014.
  21. Law TK, Yan AT, Tsigoulis M, Kajil M, Verma S, Gupta M. Gender-Related Differences in Cardiovascular Risk Assessment and Management in Primary Care: Insights from the PARADIGM Study. Can J Cardiol. 2014;30(10S):S304.
  22. Wang JY, Leiter LA, Langer A, Tan MK, Goldin L, Teoh H, Cheng AY, Connelly KA, Goodman SG, Yan AT. Glycemic Control and Cardiovascular Risk Factor Management in Patients with Diabetes With and Without Coronary Artery Disease: Insights from the Diabetes Mellitus Status In Canada (DM-SCAN) Survey. Can J Cardiol. 2014;30(10S):S79.
  23. Finken LR, Coomes E, Bajaj RR, Sharieff W, Bagai A, Cheema AN. Has Google Replaced Traditional Sources of Cardiovascular Disease and Risk Factor Information? Can J Cardiol. 2014 Oct;30(10):S 180. Oral Presentation. CCC 2014. Vancouver Oct 25-28, 2014.
  24. Ghugre N, Pop M, Qi X, Barry J, Strauss B, Wright GA. Hemorrhage promotes inflammation and myocardial damage following acute myocardial infarction. Oral Abstract at SCMR 2014, January 18, 2014, New Orleans, Louisianna, USA. Journal of Cardiovascular Magnetic Resonance 2014, 16(Suppl 1):O72.
  25. Mihaela Pop, Nilesh R Ghugre, Venkat Ramanan, Susan Newbigging, Graham A Wright. High resolution cardiac T1* maps of chronic fibrosis correlate with collagen content. Poster at IMNO 2014, March 24, 2014, Toronto, Ontario, Canada.
  26. Shariat M, Thavendiranathan P, Nguyen E, Wald R, Paul N, Wintersperger B, Crean AM. How typical are the ‘typical’ features of cardiac amyloidosis on cardiac magnetic resonance. Society of Thoracic Radiology Annual Meeting, 2014 (poster). Journal of Thoracic Imaging. 2014;29(4):W61.
  27. Wijeysundera HC, Qiu F, Micieli A, Bennell MC, Atzema C, Ko DT, Dorian P, Singh SM. Identifying Predictors of Cumulative Health Care Costs in Incident Atrial Fibrillation: a Population-Based Study. Circulation: Cardiovascular Quality and Outcomes. 2014 Jul 1;7(Suppl 1):A259-A259. Presentation at the Quality of Care and Outcomes Research 2014 Scientific Sessions, Baltimore, MD, June 2-4, 2014 in.
  28. Wijeysundera HC, Qiu F, Bennell MC, Natarajan MK, Cantor WJ, Smith S, Kingsbury KJ, Ko DT. Impact of System and Physician Factors on the Diagnostic Yield of Coronary Angiography in Stable Ischemic Heart Disease: a Population-Based Study. Circulation: Cardiovascular Quality and Outcomes. 2014 Jul 1;7(Suppl 1):A342-A342. Presentation at the Quality of Care and Outcomes Research 2014 Scientific Sessions, Baltimore, MD, June 2-4, 2014.
  29. Lu J, Christie J, Bagai A, Buller C, Cheema A, Graham J, Kutryk M, Fam N. Incidence, Characteristics and Outcomes of False Positive ST-Segment Elevation Myocardial Infarction diagnoses in a community-wide primary program. Can J Cardiol. 2014 Oct;30(10):S 114. Oral Presentation. CCC 2014. Vancouver Oct 25-28, 2014. Coauthor or Collaborator.
  30. Yang, Y, Zavodni AE, Foltz WD, Ramanan V, Vivas L, Roifman I, Wright GA. Increased myocardial extracellular volume fraction in diabetic patients is associated with LV diastolic dysfunction: a CMR feasibility study. Poster presentation at RSNA 2014, November 30, 2014, Chicago, Illinois, USA.
  31. Zhang H, Goodman SG, Yan RT, Steg PG, Kornder JM, Gyenes GT, Grondin FR, Brieger D, DeYoung JP, Gallo R, Yan AT. In-Hospital Management and Outcomes of Acute Coronary Syndromes in Relation to Prior History of Heart Failure. Can J Cardiol. 2014;30(10S):S337.
  32. Sardar P, Nairooz R, Chaterjee S, Udell JA, Kumbhani DJ, Kosiborod MN, Lavie C, Mukherjee D, McGuire DK. Intensive glycemic control in patients with acute coronary syndrome: a meta-analysis. 2014 American Heart Association Scientific Sessions, Chicago, IL. Nov. 2014
  33. Goldhar HA, Yan AT, Ko D, Earle C, Tomlinson GA, Trudeau ME, Krahn M, Krzyzanowska MK, Pal R, Brezden CB, Gavura S, Lien K, Chan KK. Long-term risk of heart failure associated with adjuvant trastuzumab in breast cancer patients. Journal of Clinical Oncology. 2014;32(15(Suppl)):9504.
  34. Alnasser S, Bagai A, Jolly S, Bertrand O, Cantor W, Cheema AN. Low Rate of Crossover to Transfemoral Approach with Substantial Reduction in Vascular Complications among Octogenarians treated with PCI via the Transradial Approach. Can J Cardiol. 2014 Oct;30(10):S 64. Poster Presentation. CCC 2014. Vancouver Oct 25-28, 2014.
  35. Shuvy M, Guo H, Wijeysundera HC, Feindel CM, Cohen EA, Austin PC, Kingsbury K, Natarajan MK, Tu JV, Ko DT. Medical Therapy and Coronary Revascularization for Patients with Stable Coronary Artery Disease and Unclassified Appropriateness Score. Circulation. 2014 Nov 25;130(Suppl 2):A14734. Poster Presentation at the American Heart Association’s 2014 Scientific Sessions in Chicago, Illinois, November 15-19, 2014.
  36. Xu R, Athavale P, Nachman A, Wright GA. Multiscale Total Variation Registration for MRI Guided Interventions. E-Poster# 3822 at ISMRM 2014, May 12, 2014, Milan, Italy.
  37. Yang Y, Zavodni A, Balter M, Zia M, Roifman I, Dick A, Connelly K, Wright GA. Myocardial extracellular space volume in patients with systemic sarcoidosis: quantitative measurement using a T1 mapping technique. Poster presentation at SCMR 2014, January 18, 2014, New Orleans, Louisianna, USA. Journal of Cardiovascular Magnetic Resonance 2014, 16(Suppl 1):P279.
  38. Wang JY, Goodman SG, Saltzman I, Wong GC, Huynh T, Dery JP, Leiter LA, Bhatt DL, Welsh RC, Spencer FA, Fox KA, Yan AT. Number of Traditional Cardiovascular Risk Factors and Management and Outcome in Acute Coronary Syndrome. Can J Cardiol. 2014;30(10S):S71.
  39. Wijeysundera DN, Ko DT, Wijeysundera HC, Yun L, Beattie S. Outcomes After Starting Beta-Blockage within a Clinically Sensible Period Before Major Elective NonCardiac Surgery. Circulation. 2014 Nov 25;130(Suppl 2):A12444. Poster Presentation at the American Heart Association 2014 Scientific Sessions, November 16, 2014, Chicago, Illinois.
  40. Dery JP, Fisher HN, Qin Y, Zhu YE, Welsh RC, Lavi S, Cieza T, Henderson M, Lutchmedial S, Mehta SR, Goodman SG. Patterns of ADP Receptor Inhibitor Use During the Index Hospitalization in Patients with Myocardial Infarction Undergoing Percutaneous Coronary Intervention: Insights from the Canadian Observational Antiplatelet Study (Coapt). Can J Cardiol. 2014. In press. In Press.
  41. Calleja A, Poulin F, Khorolsky K, Lin AE, Bedard P, McDonald M, Delgado D, Thavendiranathan P. Persistent left and right ventricular clinical and sub-clinical dysfunction is common in patients with breast cancer experiencing cardio-toxicity during therapy. American Society of Echocardiography Scientific Sessions, 2014 (poster). J Am Soc Echocardiogr. 2014;27(6):B39.
  42. Shariat M, Wintersperger B, Nguyen E, Crean A, Thavendiranathan P, Paul N. Personalized dose reduction and image optimization in CT coronary angiography using iterative reconstruction: A practical approach in 4 Easy steps! Society of Thoracic Radiology Annual Meeting, 2014 (poster). Journal of Thoracic Imaging. 2014;29(4):W61.
  43. Chun S, Qiu F, Austin P, Ko DT, Mamdani M, Czarnecki A, Bennell M, Wijeysundera HC. Predictors of Optimal Medical Therapy and Their Impact on Mortality and Readmission for Myocardial Infarction in Stable Ischemic Heart Disease Patients. J Am Coll Cardiol. 2014 Apr 1;63(12_S):A1532. Oral Presentation at the American College of Cardiology 63rd Annual Scientific Session and TCT@ACC-i2, Saturday, March 29 - Monday, March 31, 2014, in Washington, DC, USA.
  44. Tan NS, Goodman SG, Yan RT, Tan M, Fox KA, Gore JM, Brieger D, Steg PG, Langer A, Yan AT. Prognostic Significance of Low QRS Voltage on the Admission Electrocardiogram in Acute Coronary Syndromes. Can J Cardiol. 2014;30(10S):S60.
  45. Chen H, Wright GA. Protocal Optimization and Physiological Specificity of ASL-Measured Reactive Hyperemia in Skeletal Muscle. Poster presentation at SCMR 2014, January 18, 2014, New Orleans, Louisianna, USA. Journal of Cardiovascular Magnetic Resonance 2014, 16(Suppl 1):P37.
  46. Czarnecki A, Prasad T, Wang J, Cheema AN, Dzavik V, Natarajan MK, Simpson CS, So DY, Syed J, Tu JV, Wijeysundera HC, Ko DT. Quality of care and outcomes of care of percutaneous coronary interventions in Ontario. Canadian Journal of Cardiology. 2014 Oct 1;30(10 Suppl):S89. Presentation at the Canadian Cardiovascular Congress (CCC) 2014 in Vancouver, British Columbia, October 25-28, 2014.
  47. Hanneman K, Nguyen ET, Thavendiranathan P, Ward R, Greiser A, Yang IY, Sussman MS, Wintersperger BJ. Quantification of diffuse myocardial interstitial fibrosis in thalassemia major with cardiac magnetic resonance imaging. Radiological Society of North America Annual Meeting, 2014.
  48. Coomes E, Finken LR, Quadros KK, Bajaj RR, Sharieff W, Bagai A, Cheema AN. Racial and Ethnic Differences in Cardiovascular Risk Factor Prevalence and Awareness. Can J Cardiol. 2014 Oct;30(10):S 305. Poster Presentation. CCC 2014. Vancouver Oct 25-28, 2014.
  49. Thavendiranathan P, Amir E, Bedard PL, Crean A, Paul N, Nguyen ET, Wintersperger BJ. Regional myocardial edema detected by T2 mapping is a feature of cardiotoxicity in breast cancer patients receiving sequential therapy with anthracyclines and trastuzumab. Society of Cardiovascular Magnetic Resonance Scientific Sessions, 2014 (poster). JCMR. 2014:16(S1):P273.
  50. Mohareb MM, Qui F, Cantor WJ, Kingsbury KJ, Ko DT, Wijeysundera HC. Relationship Between Appropriateness of Elective Coronary Angiography and Diagnostic Yield for Obstructive Coronary Artery Disease. Circulation. 2014 Nov 25;130(Suppl 2):A13206. Poster Presentation at the American Heart Association 2014 Scientific Sessions, November 16, 2014, Chicago, Illinois.
  51. Chan M, Neely ML, Roe MT, Goodman SG, Cornel JH, Zhou C, Jakubowski JA, Fox KAA, Armstrong PW, White HD, Prabhakaran D, Ohman EM, Huber K. Relationship of Longitudinal Measurements of Biomarkers of Hemodynamic Stress, Systemic Inflammation, and Platelet Reactivity with Ischemic Outcomes in Non-ST -Segment Elevation Acute Coronary Syndrome Patients Managed Without Revascularization: Insights from the TRILOGY ACS Trial. Circulation. 2014;130(Suppl 2).
  52. Calleja A, Poulin F, Khorolosky K, McDonald M, Delgado D, Thavendiranathan P. Right ventricular dysfunction in patients with breast cancer experiencing cardiotoxicity during trastuzumab therapy. Canadian Cardiooncology Network Meeting, 2014, Research Award (3rd Prize).
  53. Alnasser SM, Bagai A, Jolly S, Cantor W, Bertrand O, Cheema AN. Safety and Efficacy of transradial approach for coronary angiography and intervention in the elderly: A systemic review and meta-analysis. JACC. 2014 Apr 1;63(12 _Suppl1):A1807. Poster Presentation. ACC 2014, Washington D.C., March 29 – 31, 2014.
  54. Verma S, Goodman SG, Latter D, Ruel M, Ahsan MR, Gupta M, Gupta N, Teoh H, Friedrich JO. Should Dual Antiplatelet Therapy Be Used After Coronary Artery Bypass Surgery? A Meta-Analysis of 4662 Patients from Randomized Controlled Trials. Can J Cardiol. 2014;30(10S):S160.
  55. Cheema AN, Al Lawati H, Bagai A, Eisenberg M, Shimony A, So D, Karp I, Pilote L, for the Genesis Praxy Investigators. Spontaneous coronary artery dissection in young women presenting with acute coronary syndrome: Angiographic findings from the Genesis Praxy study. JACC. 2014 Apr 1;63(12 _Suppl1):A3. Poster Presentation. ACC 2014, Washington D.C., March 29 – 31, 2014.
  56. Bagai A, Chaitman BR, Gosselin G, Shah BN, Diaz A, Humen D, Banerjee S, Perna GP, Schuchlenz H, Cheema AN, Wu, Y, Kronenberg MW, Aronow HD, Miller TD, El-Hajjar M, Druz R, Pracon R, Newby LK, Alexander K, Goodman S, Bangalore S, Maron DJ, Hochman JS, Mahaffey KW. Substantial variability between laboratories in Troponin decision level for diagnosis of myocardial infarction and assay 99th percentile: Findings from the international study of comparative health effectiveness with medical and invasive approaches (Ischemia) trial. JACC. 2014 Apr 1;63(12 _Suppl1):A1878. Poster Presentation. ACC 2014, Washington D.C., March 29 – 31, 2014.
  57. Deghani P, Rezaei E, Bagai A, Al Nasser S, Al Lawati H, Cheema AN. Successive Transradial Approach is Associated with an Acceptable Success Rate and a Lower Risk of Vascular Complications compared to the Transfemoral Approach in Patients undergoing Repeat Percutaneous Coronary Intervention. Can J Cardiol. 2014 Oct;30(10):S 92-93. Poster Presentation. CCC 2014. Vancouver Oct 25-28, 2014.
  58. Ting R, Alnasser S, Parthasarathy H, Bagai A, Sharieff W, Finken L, Cheema AN. A Systematic Review and Meta-Analysis of Two-Stent Techniques for the Treatment of Coronary Bifurcation Lesions. Can J Cardiol. 2014 Oct;30(10):S 99. Poster Presentation. CCC 2014. Vancouver Oct 25-28, 2014.
  59. Yousef A, Simard T, Webb J,Rodés-Cabau J, Costopoulos C, Kochman J, Hernández-Garcia J, Chiam PT, Welsh R, Wijeysundera H, García E, Ribeiro H, Latib A, Huczek Z, Shanks M, Testa L, Farkouh M, Dvir D, Velianou J, Lam B, Pourdjabbar A, Glover C, Hibbert, Labinaz M:. Transcatheter aortic valve implantation in patients with bicuspid aortic valve: Patient level International multi-center analysis. Circulation. 2014 Nov 25;130(Suppl 2):A19787. Poster Presentation at the American Heart Association’s 2014 Scientific Sessions in Chicago, Illinois, November 15-19, 2014.
  60. Natarajan MK, Forsey A, Wijeysundera HC, Oakes G, Cantor WJ, Kassam SA , K Kingsbury. Trends In PCI for Patients with ST-Segment Elevation Myocardial Infarction at Ontario Cardiac Centres with and without On-Site Cardiac Surgery. Canadian Journal of Cardiology. 2014 Oct 1;30(10 Suppl):S67. Poster presentation at the Canadian Cardiovascular Congress (CCC) 2014 in Vancouver, British Columbia, October 25-28, 2014. .
  61. Ting RD, Parthasarathy H, Bagai A, Sharieff W, Finken L, Cheema AN. Two stent techniques for treatment of coronary bifurcation lesions: a systematic review and meta analysis. CCI Cardiac Catherization and Intervention. 2014 May. Poster Presentation. SCAI 2014 Scientific Sessions (The Society for Cardiovascular Angiography and Interventions), Las Vegas, May 28 – 31, 2014.
  62. Shariat M, Thavendiranathan P, Nguyen ET, Wintersperger BJ, Paul N, Rakowski H, Crean AM. Utility of computed tomography coronary angiography in patients with hypertrophic cardiomyopathy presenting with stable angina. Radiological Society of North America Annual Meeting, 2014.

Grants

Grants by NICR Members

Sorted alphabetically by last name
  1. Connelly, Kim – Canadian Institutes of Health Research (CIHR) New Investigator Award. $300,000 - July 2014
  2. Connelly, Kim - Principal Investigator. CD34+ Cell therapy for Diabetic Cardio-Renal Disease. Diabetes and Heart Disease Research-Directed Grant Program sponsored by Banting and Best Diabetes Center/Heart & Stroke Richard Lewar Centre/University of Toronto Faculty Medicine. 250,000 CAD. [Grants] 2014 Apr – 2016 Mar
  3. Connelly, Kim - Co-Investigator - Heart and Stroke Foundation of Ontario Grant.Role of ROS in diabetes cardiac complications. $240,000 - July 2014- June 2017
  4. Connelly, Kim – Co-Investigator - Heart and Stroke Foundation of Ontario Grant. Metabolic Imaging of the Hypertrophic Heart.(Principal Investigator- Charles Cunningham; Collaborator: Graham Wright). $239,625 CAD. July 2014 – July 2017
  5. Connelly, Kim – The Ministry of Research and Innovation - Early Researcher Award. $140,000 - May 2014
  6. Connelly, Kim – Co-Investigator - Heart and Stroke Foundation of Ontario Grant. Impact of in-centre nocturnal hemodialysis on ventricular remodeling and function in end-stage renal disease. (Principal Investigator - Andrew Yan; Collaborator - Ron Wald). $116,641. July 2014
  7. Dorian, Paul - Co-investigator & Member of Steering Committee - Canadian Institutes of Health Research (CIHR) - ICRH Emerging Network Grants– Full Application. Canadian stroke prevention intervention network (C-SPIN) (Principal Investigator – Jeff Healey) $4,350,000 - 10/2013 - 09/2018
  8. Dorian, Paul - Co-investigator - Canadian Institutes of Health Research (CIHR) Operating Grant. Role of oxidative stress and TNF-alpha in exercise-induced atrial fibrillation (Principal Investigator – Peter Backx) $762,213 - 04/2012 - 03/2017
  9. Dorian, Paul - Co-investigator- Canadian Institutes of Health Research (CIHR) Operating Grant - Assessing and improving the quality of care of patients with out-of hospital cardiac arrest (Principal Investigator – Dennis Ko) $443,022 - 10/2013 -09/2016
  10. Dorian, Paul – Co-investigator - Heart & Stroke Foundation of Canada (HSFC) Grant-in-Aid. Atrial Fibrillation in the Emergency Room (The AFTER Study): Prospective validation of a clinical decision instrument. (Principal Investigator – Clare Atzema); Collaborators: Lee DS, Tu JV, Austin PC. $299,584 - 03/2015 - 04/2018
  11. Dorian, Paul - Co-investigator - Canadian Institutes of Health Research (CIHR) Operating Grant. Pilot KT intervention to address gender differences in access to post arrest care - (Principal Investigator – Laurie Morrison) $218,994 - 06/2012 - 05/2014
  12. Dorian, Paul - Co-investigator - Heart & Stroke Foundation of Canada. Improving stroke prevention for patients with atrial fibrillation in primary care (Principal Investigator – Dante Morra) $ 211,261 - 04/2013 - 03/2016
  13. Dorian, Paul - Co-investigator - Canadian Institutes of Health Research (CIHR) Operating Grant. Cardiac consequences of excessive exercise (Principal Investigator – Jack Goodman) $199,196 - 10/2013 - 09/2016
  14. Dorian, Paul – Co-investigator - AHSC AFP Innovation Fund. Optimizing cerebral perfusion in cardiac arrest resuscitation. (Principal Investigator – Steve Lin) $109,649 - 11/2013 -10/2015
  15. Dorian, Paul - Co-investigator - AHSC AFP Innovation Fund. Using simulated cardiac arrest to study and improve first responder adherence to BLS guidelines in SMH - (Principal Investigator – Natalie Wong) $46,956 - 12/2012 - 11/2013
  16. Farkouh, Michael – Co-Principal Investigator - Canadian Institutes of Health Research (CIHR) Grant. The CORRELATE Study - Canadian Outcomes Registry Late After Tetralogy of Fallot Repair. $771,662 - 3/01/12 – 9/01/15
  17. Farkouh, Michael – Collaborator - Canadian Institutes of Health Research (CIHR) Grant. CHF-CePPORT - Canadian 2-Platform to Promote Behavioural Self-Management in Chronic Heart Failure. $653,666 - 03/2013 – 06/2016
  18. Ko, Dennis - Principal Investigator - Ontario Transcatheter Aortic Valve Implantation Report Card. Cardiac Care Network of Ontario (CCN). PI: Humphries, Karin - $350,000. 2014 – 2015
  19. Ko, Dennis - Co-Investigator - Canada Data Definitions and Quality Indicators. Public Health Agency of Canada (PHAC). PI: Humphries, Karin - $350,000. 2013 - 2015
  20. Lee, Douglas - Co-Investigator - Canadian Institutes of Health Research (CIHR) Operating Grant (location- Sunnybrook). Statistical Methods for Health Services Research. PI: Peter Austin - $214,105- 2014 (5 years)
  21. Lee, Douglas - Principal Investigator - Toronto Central Local Health Integration Network Grant (location- UHN & ICES). CHF Phase II. $150,000 - 2014
  22. Lee, Douglas - Co-Investigator - Innovation in Quality Award, Division of Cardiology (location- UofT). Developing and Implementing a Strategy to Improve Heart Failure Outcomes in Patients with Multiple Co-morbidities. PI: Sacha Bhatia. $70,000 - 2014
  23. Lee, Douglas - Co-Investigator - Canadian Institutes of Health Research (CIHR) Planning and Dissemination Grant (location- Sunnybrook). Addressing the Frequency and Timeliness of Follow-up Care After a Visit to the Emergency Department in Patients with Chronic Disease. PI: Clare Atzema - $20,000 – 2014-2015
  24. Leong-Poi, Howard - Principal Investigator - Canadian Institutes of Health Research Research (CIHR) Operating Grant. Next Generation Ultrasound-Mediated Gene Delivery: Targeting Acute Myocardial Infarction-Reperfusion. $93,693 - 2014-2015
  25. Lok, Charmaine – Mid-Career Investigator Award – A Program of cardiovascular health improvement in chronic and endstage kidney disease, Heart and Stroke Foundation, Ontario. $320,000 – 2014-2018
  26. Lok, Charmaine – Principal Investigator. The impact of exercise on vascular remodeling, arteriovenous fistula creation and use in patients with chronic kidney disease: a randomized controlled trial. Physicians Services Incorporated Foundation (The) (PSI). $170,000 - 2014-2015
  27. Lok, Charmaine – Co-Principal Investigator. Evaluation of self-care medication reconciliation app for patients with chronic kidney disease. Canadian Institutes of Health Research (CIHR)
  28. Lok, Charmaine – Principal Investigator: PISCES: Protection against Incidences of Serious Cardiovascular Events Study with Fish Oil Supplementation in Dialysis Patients at UHN, PMCC Innovation Fund
  29. Thavendiranathan P. - Principal Investigator - Canadian Institute of Health Research Bridge Funding. Evaluation of myocardial changes during breast adenocarcinoma therapy to detect cardiotoxicity earlier with MRI – The EMBRACE-MRI. $100,000 July 2014
  30. Thavendiranathan P. - Principal Investigator - Canadian Institute of Health Research New Investigator Bridge Funding. Evaluation of myocardial changes during breast adenocarcinoma therapy to detect cardiotoxicity earlier with MRI – The EMBRACE-MRI. $100,000 - January 2014
  31. Thavendiranathan P. - Co-Investigator - University of Toronto Dean’s Fund. Intense chelation therapy for severe myocardial iron overload: monitoring with multi-parametric MRI mapping techniques. $20,000 - February 2014
  32. Thavendiranathan P. - Principal Investigator - Heart and Stroke Foundation/University of Toronto Polo Chair in Cardiology Young Investigator Award 2014. Association between left and right ventricular dysfunction and long term cardiac outcomes in women with breast cancer receiving cancer therapy. $16,874 - October 2014
  33. Wijeysundera, Harindra– Co-Investigator - Canada Foundation for Innovation (CFI) New Initiatives Fund (2012 competition). Centre for the Evaluation of Technological Innovation (CETI). PI: Krahn, Murray. Collaborator(s): Alibhai, Shabbir;Bayoumi, Ahmed; Cadarette, Suzanne; Coyte, Peter; Grootendorst, Paul; Miller, Fiona; Ungar, Wendy; Wijeysundera, Harindra; Zwarenstein, Merrick. $1,199,915 - 2013 Jul - 2016 Jun
  34. Wijeysundera, Harindra– Co-Investigator - Canadian Institutes of Health Research (CIHR) Team Grant: Chronic Disease Risk and Intervention Strategies. Measuring and improving the quality of ambulatory care for people with cardiovascular risk factors and/or chronic cardiovascular diseases. PI: Jack Tu. Collaborator(s): David Alter, Clare Atzema, Peter Austin, Gillian Booth, Maria Chu, Richard Glazier, Moira Kapral, Dennis Ko, Douglas Lee, Douglas Manuel, Jillian Oderkirk, Claudi Sanmartin, Gustavo Saposnik, Baiju Shah Therese Stukel, Karen Tu, Harindra Wijeysundera. $1,998,739 - 2011 Dec - 2016 Nov
  35. Wijeysundera, Harindra- Principal Investigator - Medtronic Canada through MaRS Excellence in Clinical Innovation and Technology Evaluation (EXCITE). A Pragmatic Randomized Clinical Evaluation of Renal Denervation for Treatment Resistant Hypertension (PaCE). Collaborator(s): Al-Hesayen, Abdul; Cohen, Eric A; Farkouh, Micheal; Floras, John; Froeschel, Michael; Graham, John J; Logan, Alexander; Mamdani, M.; Mendelssohn, David C; Milne, Laura; Parfrey, Brendon; Rajan, Dheeraj; Rubin, Barry; Ruzicka, Marcel; Thorpe, Kevin; Tobe, Sheldon. $1,042,182 - 2013 Apr - 2015 Jan
  36. Wijeysundera, Harindra– Co-Investigator - Canadian Institutes of Health Research (CIHR) Operating Grant. Measuring and Improving the Quality of ST-segment Myocardial Infarction (STEMI) Care. PI: Jack V Tu. Collaborator(s): C. Atzema, P. Austin, J. Cox, T. Huynh, C. Jackevicius, D. Ko, L. Lambert, D. Lee, M. Natarajan, D. So, T. Stukel, H Wijeysundera. $995,920 - 2011 Apr - 2015 Mar
  37. Wijeysundera, Harindra– Co-Investigator - Canadian Institutes of Health Research (CIHR) Operating Grant. The METS (Measurement of Exercise Tolerance before Surgery) Study: An International Multicentre Prospective Cohort Study of Cardiopulmonary Exercise Testing For Improving Preoperative Risk Stratification for Major Non-Cardiac Surgery. PI: Wijeysundera, Duminda N. & Cuthbertson, Brian H. Collaborator(s): W. Beattie, V. Chan, B. Croal, J. Granton, J. Hoch, M. Mamdan, D. Mazer, C. Mccartney, P. Oh, R. Pearse, A. Smith, K. Thorpe, H. Wijeysundera. $987,068 - 2012 Apr - 2016 Mar
  38. Wijeysundera, Harindra– Co-Investigator - Canadian Institutes of Health Research (CIHR) Operating Grant. ACUTE Study: Acute Congestive Heart Failure Urgent and Transitional Care Evaluation. PI: Lee, Douglas. Collaborator(s): D Alter, P Austin, B Borgundvaag, J Brehaut, M Edmonds, S Friedman, J Grimshaw, J Lee, M Schull, T Stukel, J Tu, H Wijeysundera. $518,688 - 2011 Oct - 2015 Sep
  39. Wijeysundera, Harindra- Principal Applicant - Heart and Stroke Foundation of Canada (HSFC) Distinguished Clinician Scientist award. Evaluating Therapeutic Decision-Making, Outcomes & Resource Utilization in Chronic Stable Angina: an interprovincial population-based study. $500,000 - 2013 Jul - 2018 Jun
  40. Wijeysundera, Harindra– Co-Investigator - Canadian Institutes of Health Research (CIHR). Operating Grant. Assessing and improving the quality of care of patients with out-of-hospital cardiac arrest. PI: Ko, Dennis. Collaborator(s): Austin P, Cheskes S, Dorian P, Morrison L, Rac V, Scales D, Stukel T, Tu J, Verbeek P, Wijeysundera H. $443,022 - 2014 Apr - 2017 Mar
  41. Wijeysundera, Harindra– Co-Investigator - Heart and Stroke Foundation of Canada (HSFC) Grants-in-aid. Improving the assessment and treatment of severe aortic stenosis by evaluating care gaps and advancing risk predictions. PI: Ko, Dennis. Collaborator(s): D. Alter, P. Austin, W. Cantor, A. Cheema, M. Chu, S. Fremes, M. Natarajan, M. Ruel, B. Strauss, T. Stukel, J. Tu, H Wijeysundera. $331,058 - 2012 Jul - 2015 Jun
  42. Wijeysundera, Harindra- Principal Investigator - Canadian Institutes of Health Research (CIHR). Operating Grant. Evaluating Therapeutic Decision-Making, Outcomes and Resource Utilization in Chronic Stable Angina: an interprovincial population-based study. Collaborator(s): AUSTIN, Peter C; GHALI, William A; Hoch, Jeffrey S; Knudtson, Merril L; Ko, Dennis T.; Norris, Colleen; Tu, Jack V. $221,999 - 2012 Oct - 2015 Sep
  43. Wijeysundera, Harindra– Co-Investigator - Heart and Stroke Foundation of Canada (HSFC) Grants-in-Aid. The METS (Measurement of Exercise Tolerance before Surgery) Study: An International Multicentre Prospective Cohort Study of Cardiopulmonary Exercise Testing For Improving Preoperative Risk Stratification for Major Non-Cardiac Surgery. PI: Wijeysundera, Duminda. $144,000 - 2013 Jul - 2016 Jun
  44. Wijeysundera, Harindra- Principal Investigator - Medtronic Canada through MaRS Excellence in Clinical Innovation and Technology Evaluation (EXCITE). Economic Evaluation of Renal Nerve Denervation for Treatment Resistant Hypertension in Ontario. Collaborator(s): Krahn, Murray. $97,604 - 2013 Apr - 2015 Jan
  45. Wijeysundera, Harindra- Principal Investigator - Sunnybrook Medical Services Alternative Funding Plan (AFP) Association Innovation Funds. Closing the Quality Feedback Loop: A Web-Based Forum to Improve the Quality of Care and Outcomes of the Toronto Heart Attack Collaborative (THAC) Regional STEMI Program. $80,961 - 2012 Jun - 2014 May
  46. Wijeysundera, Harindra- Co-Principal Investigator - Heart & Stroke Foundation/University of Toronto Polo chair in Cardiology Young Investigator Award. Resource Utilization of New Onset Atrial Fibrillation – A Population Based Evaluation. (Co-PI: Singh, Sheldon). $26,654 - 2013 Oct - 2014 Sep
  47. Wijeysundera, Harindra- Co-Principal Investigator - Heart & Stroke Foundation/University of Toronto Polo chair in Cardiology Young Investigator Award. Effectiveness and Safety of Catheter Ablation Procedures for Atrial Fibrillation in Ontario, Canada (Co-PI: Singh, Sheldon). $11,702 - 2014 Oct - 2015 Sep
  48. Wijeysundera, Harindra- Principal Investigator - Heart & Stroke Foundation/University of Toronto Polo Chair in Cardiology Young Investigator Award. Predictors of Wait‐Times for Patients with Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Implantation (TAVI): A Population Based Study. $11,702 - 2014 Oct - 2015 Sep
  49. Wright, Graham – Principal Investigator - Canadian Institutes of Health Research (CIHR) Operating Grant. MRI for Arrhythmia Management in Ischemic Heart Disease. Co-applicants: Eugene Crystal, Sheldon Singh. $820,920 - 04/2014-03/2019
  50. Wright, Graham – Principal Investigator - Apopharma Inc. Effects of deferiprone on myocardial infarction and cardiac remodeling in a porcine model of acute aschemia-reperfusion injury. $296,460 - 08/2014-01/2015
  51. Wright, Graham – Co-Applicant - Heart & Stroke Foundation of Canada, Grant-in-Aid Program. Metabolic Imaging of the Hypertrophic Heart. PIs: Charles H. Cunningham. Co-applicants: Graham A. Wright, Kim Connelly. $239,625 - 07/2014-06/2017
  52. Wright, Graham – Co-Applicant - Heart & Stroke Foundation of Canada, Grant-in-Aid Program. Impact of In Centre hemodialysis on Cardiac Remodeling in end-stage renal disease: a long term follow-up study. PIs: Andrew Yan. Co-applicants: Graham A. Wright, Marc Goldstein, Ron Wald, Darren Yuen, Anish Kirpalani, Gerald Lebovic, Mercedeh Kiaii, Jonathan Leipsic, Howard Leong-Poi, Kim Connelly. $135,915 - 07/2014-06/2017
NOTE: We wish to regularly highlight NICR members’ achievements and welcome submissions. Please contact Tracey Richards at hsrl.centre@utoronto.ca so we can add yours.

Awards

Awards by NICR Members

Sorted alphabetically by last name
  1. Floras, John - F.C.A.H.S. (Fellow of the Canadian Academy of Health Sciences) 2014
  2. Ko, Dennis - Article of the Year Award, CIHR, Institute of Health Services and Policy Research, Canada. (Research Award) for the study “Prevalence and extent of obstructive coronary artery disease among patients undergoing elective catheterization in New York State”. 2013-2014
  3. Lee, Douglas - Canadian Cardiovascular Society Dr. Robert E. Beamish Award. Given in honour of Dr. Robert E. Beamish, founding Editor-in-Chief of The Canadian Journal of Cardiology, to the author of an original research article published during the preceding three years that has been judged to have the greatest potential impact on cardiovascular medicine. 2014
  4. Lee, Douglas - Supervisor of Wael Abuzeid, MD. First Prize, Ursula Bangs Research Competition. Winner, Young Investigator Award 2014, American Society of Nuclear Cardiology. Project Title: Prognostic impact of SPECT MPI after renal transplantation.
  5. Thavendiranathan P. - Canadian Cardiac Oncology Network 3rd Prize Abstract Research Award
  6. Thavendiranathan P. - Nominated for the University of Toronto Wightman-Berris Academy Teaching Award
  7. Thavendiranathan P. - UHN William McDiarmid Scholarship Award for Graduate Studies
  8. Udell, Jacob A. – CanMEDs Education Award, Cardiology, Dept of Medicine, Faculty of Medicine, Women’s College Hospital. This award recognizes continuing excellence in education leadership.
  9. Udell, Jacob A. – CIHR Rising Star Award – Institute of Health Services and Policy Research (Research Award) to recognize excellence in Canadian knowledge translation and/or research carried out by graduate students and post-doctoral fellows in all fields and disciplines related to health services and policy research.
  10. Udell, Jacob A. – Outstanding Paper Award (Trainee), Women’s College Research Institute, Women’s College Hospital, Toronto, ON, Canada
  11. Udell, Jacob A. – Teacher/Education Award, Women’s College Hospital. This award recognizes a health care professional who has demonstrated exceptional commitment to clinical teaching at WCH.
  12. Wijeysundera, Harindra - CIHR New Investigator award, Canadian Institutes of Health Research (CIHR), Canada. (Distinction) 2013 Jul - 2018 Jun
  13. Wijeysundera, Harindra - Department of Medicine Merit Award, University of Toronto, Ontario, Canada. (Salary Support) $75,000 - 2014 Jul - 2017 Jun
  14. Wijeysundera, Harindra - Distinguished Clinician Scientist, Heart and Stroke Foundation of Canada (HSFC), Canada. (Distinction) $500,000 - 2013 Jul - 2018 Jun
  15. Wijeysundera, Harindra - SHSC Department of Medicine Junior Investigator Award for 2014, Sunnybrook Health Sciences Centre. (Distinction) 2014
NOTE: We wish to regularly highlight NICR members' achievements and welcome submissions. Please contact Tracey Richards at hsrl.centre@utoronto.ca so we can add yours.

Media Apperances

Media Appearances by NICR Members

Sorted alphabetically by last name
  1. Farkouh, Michael - Sirius Satellite Radio, Doctor Radio January 7, 2015, Heart Disease News of the Day
  2. Farkouh, Michael – Sirius Satellite Radio, Doctor Radio April 2, 2014, New Cardiology Studies
  3. Farkouh, Michael – CBC Newsworld, October 22, 2013, Heart Benefits of the Flu Shot
  4. Farkouh, Michael – CITY TV Toronto, October 21, 2013, Heart Benefits of the Flu Shot
  5. Udell, Jacob A. - CBC The National's Checkup panel: flu season facts. Interviewed by Peter Mansbridge. Jan. 27, 2015 http://bit.ly/1EsvpQB
  6. Udell, Jacob A. - Ask a Cardiologist Blog: "I've been diagnosed with depression. Could this affect my heart health?" Heart and Stroke Foundation of Canada. Jan. 23, 2015 http://bit.ly/1FXK8oc
  7. Udell, Jacob A. - Diabetes drug safe for heart in renal patients. Coverage by Medpage Today. Jan. 15, 2015 http://bit.ly/1JM0lzH
  8. Udell, Jacob A. - Cardiologist to fellow docs: flu shots benefit heart, too. Interviewed by Angela Marsall of Cardiovascular Business. Jan. 13, 2015 http://bit.ly/1wdysF9
  9. Udell, Jacob A. - Saxagliptin: a therapy option in diabetes and renal failure. Coverage by Medscape and theheart.org. Jan. 13, 2015. http://bit.ly/1wdymxk
  10. Udell, Jacob A. - Ask a Cardiologist Blog: "should I get a flu shot this year?" Heart and Stroke Foundation of Canada. Nov. 21, 2014 http://bit.ly/1LDmqMl
  11. Udell, Jacob A. - Platelet activation seen as key to link between MI and community-acquired pneumonia. Interviewed by Michael O'Riordan of Medscape/theheart.org for commentary on this research paper. Oct. 28, 2014 http://bit.ly/1DTUKSE .
  12. Udell, Jacob A. – Cardiac trials skewed by healthier-than-average test subjects. Coverage by Toronto Star, Canadian Press, US News and World Report, Metronews, Huffington Post, HealthDay, Medscape, theheart.org, and others. In total, over 100 online, television, radio, and print articles covered the report of this paper. Aug. 27, 2014
  13. Udell, Jacob A. – Highlights of the Latest Research on Heart Health. Interviewed by Canadian Living Magazine to comment. – July 22, 2014
  14. Udell, Jacob A. – Prasugrel in STEMI by PCI timing. Interviewed by Thomson Reuters for a report of this research paper. June 17, 2014
  15. Udell, Jacob A. – Snow Shoveling and Heart Risk. Interviewed by CBC Radio Toronto to comment. March 12, 2014
  16. Udell, Jacob A. – 2014 Heart and Stroke Foundation of Canada Report on Canadians’ Health: Bringing Survivors Home. Provided media interviews on the HSFC annual report card of the health of Canadians with the aim of knowledge translation to improve the health of the general public. Feb 3, 2014
NOTE: We wish to regularly highlight NICR members’ achievements and welcome submissions. Please contact Tracey Richards hsrl.centre@utoronto.ca so we can add yours.

ESC 2015 Presentations

PRESENTATIONS BY NICR MEMBERS AT THE ESC CONGRESS 2015 - August 29-September 2, 2015 - London, UK

Presentations August 29th Warsaw - Village 8 Session: Pregnancy and Heart Disease- What we Know! Where to go? 12:11 Future Direction for Research in pregnancy and heart disease Dr. Candice Silversides August 30th Hyde Park - The Hub Session: CLINICAL TRIAL UPDATE I – CARDIOVASCULAR DISEASES: PREVENTION, OUTCOMES, QUALITY 14:30 The Influence of Baseline Systolic Blood Pressure on Major Cardiovascular and Cerebrovascular Outcomes in the FREEDOM Trial: FREEDOM BP. Dr. Michael Farkouh August 31st HydePark-The Hub Session: Clinical trial update II- Antiplatelet Therapy 14:00 Long-term dual antiplatelet therapy for secondary prevention of cardiovascular events in patients with previous myocardial infarction: a collaborative meta-analysis of randomised trials. Dr. Jay Udell 2015 ESC CTU Slides- Long-term DAPT after MI